Microarray: An approach for current drug targets

Virendra S. Gomase, Somnath Tagore, Karbhari V. Kale

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Microarrays are a powerful tool has multiple applications both in clinical and cellular and molecular biology arenas. Early assessment of the probable biological importance of drug targets, pharmacogenomics, toxicogenomics and single nucleotide polymorphisms (SNPs). A list of new drug candidates along with proposed targets for intervention is described. Recent advances in the knowledge of microarrays analysis of organisms and the availability of the genomics sequences provide a wide range of novel targets for drug design. This review gives different process of microarray technologies; methods for comparative gene expression study, applications of microarrays in medicine and pharmacogenomics and current drug targets in research, which are relevant to common diseases as they relate to clinical and future perspectives.

Original languageEnglish
Pages (from-to)221-231
Number of pages11
JournalCurrent Drug Metabolism
Volume9
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Keywords

  • Biomarker
  • DNA arrays
  • FISH
  • Gene expression
  • IHC
  • Microarrays
  • Oligonucleotide

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