Abstract
Micelle Encapsulation Zinc-doped copper oxide nanocomposites (MEnZn-CuO NPs) is a novel doped metal nanomaterial prepared by our group based on Zinc doped copper oxide nanocomposites (Zn-CuO NPs) using non-micellar beam. Compared with Zn-CuO NPs, MEnZn-CuO NPs have uniform nanoproperties and high stability. In this study, we explored the anticancer effects of MEnZn-CuO NPs on human ovarian cancer cells. In addition to affecting cell proliferation, migration, apoptosis and autophagy, MEnZn-CuO NPs have a greater potential for clinical application by inducing HR repair defects in ovarian cancer cells in combination with poly (ADP-ribose) polymerase inhibitors for lethal effects.
| Original language | English |
|---|---|
| Article number | e10507 |
| Journal | Bioengineering and Translational Medicine |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2023 |
Bibliographical note
Publisher Copyright:© 2023 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.
Funding
This research was supported by the Natural Science Foundation of Sichuan (No# 2022YFS0614, 2019JDJQ0033, 2023NSFSC1675), the Central Nervous System Drug Key Laboratory of Sichuan Province (No# 200015‐01SZ and 230004‐01SZ) and the Science and Technology Project of Luzhou Government (2022YFS0614‐B1). The work was also supported by Southwest Medical University (No# 2022ZD013, 2022QN001 and 2020ZRQNB036).
| Funders | Funder number |
|---|---|
| Central Nervous System Drug Key Laboratory of Sichuan Province | 200015‐01SZ, 230004‐01SZ |
| Science and Technology Project of Luzhou Government | 2022YFS0614‐B1 |
| Southwest Medical University | 2020ZRQNB036, 2022ZD013, 2022QN001 |
| Natural Science Foundation of Sichuan Province | 2019JDJQ0033, 2023NSFSC1675, 2022YFS0614 |
Keywords
- HR repair
- MEnZn-CuO NPs
- PARP inhibitors
- antitumor mechanisms
- ovarian cancer
