MHC-multimer guided isolation of neoepitopes specific T cells as a potent-personalized cancer treatment strategy

Roni Bareli; Cyrille J. Cohen

doi:10.1080/2162402X.2016.1159370

MHC-multimer guided isolation of neoepitopes specific T cells as a potent-personalized cancer treatment strategy

Roni Bareli, Cyrille J. Cohen

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Analysis of genomic data from patient tumors provides valuable information as to potential T-cell targets such as neoepitopes. We developed an approach to characterize, isolate and utilize neoantigens-specific T cells using MHC/peptide tetramers from fresh tumor digests and peripheral blood. This bears important implications for the implementation of T cell-based immunotherapy.

Original language	English
Article number	e1159370
Pages (from-to)	e1159370
Journal	OncoImmunology
Volume	5
Issue number	7
DOIs	https://doi.org/10.1080/2162402X.2016.1159370
State	Published - 2 Jul 2016

Bibliographical note

Publisher Copyright:
© 2016 Taylor & Francis Group, LLC.

Keywords

Immunotherapy
MHC multimers
T-cells
TCR
neoantigens
tumor immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/2162402X.2016.1159370

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MHC-multimer guided isolation of neoepitopes specific T cells as a potent-personalized cancer treatment strategy

Abstract

Bibliographical note

Keywords

UN SDGs

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