TY - JOUR
T1 - Methods of epidemiology
T2 - Evaluating the fatg-breast cancer hypothesis g- comparing dietary instruments and other developments
AU - Freedman, Laurence S.
AU - Kipnis, Victor
AU - Schatzkin, Arthur
AU - Potischman, Nancy
PY - 2008/3
Y1 - 2008/3
N2 - Results from several large cohort studies that were reported 10 to 20 years ago seemed to indicate that the hypothesized link between dietary fat intake and breast cancer risk was illusory. In this article, we review several strands of more recent evidence that have emerged. These include two studies comparing the performance of dietary instruments used to investigate the dietary fat- breast cancer hypothesis, a large randomized disease prevention trial, a more recent meta-analysis of nutritional cohort studies, and a very large nutritional cohort study. Each of the studies discussed in this article suggests that a modest but real association between fat intake and breast cancer is likely. If the association is causative, it would have important implications for public health strategies in reducing breast cancer incidence. The evidence is not yet conclusive, but additional follow-up in the randomized trial, as well as efforts to improve dietary assessment methodology for cohort studies, may be sufficient to provide a convincing answer.
AB - Results from several large cohort studies that were reported 10 to 20 years ago seemed to indicate that the hypothesized link between dietary fat intake and breast cancer risk was illusory. In this article, we review several strands of more recent evidence that have emerged. These include two studies comparing the performance of dietary instruments used to investigate the dietary fat- breast cancer hypothesis, a large randomized disease prevention trial, a more recent meta-analysis of nutritional cohort studies, and a very large nutritional cohort study. Each of the studies discussed in this article suggests that a modest but real association between fat intake and breast cancer is likely. If the association is causative, it would have important implications for public health strategies in reducing breast cancer incidence. The evidence is not yet conclusive, but additional follow-up in the randomized trial, as well as efforts to improve dietary assessment methodology for cohort studies, may be sufficient to provide a convincing answer.
KW - Breast cancer
KW - Dietary fat
KW - Dietary measurement error
KW - Food frequency questionnaire
KW - Multiple-day food record
UR - http://www.scopus.com/inward/record.url?scp=50949129857&partnerID=8YFLogxK
U2 - 10.1097/PPO.0b013e31816a5e02
DO - 10.1097/PPO.0b013e31816a5e02
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C2 - 18391610
AN - SCOPUS:50949129857
SN - 1528-9117
VL - 14
SP - 69
EP - 74
JO - Cancer Journal (United States)
JF - Cancer Journal (United States)
IS - 2
ER -