Methacrylate Cationic Nanoparticles Activity against Different Gram-Positive Bacteria

Syong H. Nam-Cha, Ana V. Ocaña, Ramón Pérez-Tanoira, John J. Aguilera-Correa, Abraham J. Domb, Marta C. Ruiz-Grao, Sandra Cebada-Sánchez, Ángel López-Gónzalez, Milagros Molina-Alarcón, Juan Pérez-Martínez, Francisco C. Pérez-Martínez

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1 Scopus citations


Nanotechnology is a developing field that has boomed in recent years due to the multiple qualities of nanoparticles (NPs), one of which is their antimicrobial capacity. We propose that NPs anchored with 2-(dimethylamino)ethyl methacrylate (DMAEMA) have antibacterial properties and could constitute an alternative tool in this field. To this end, the antimicrobial effects of three quaternised NPs anchored with DMAEMA were studied. These NPs were later copolymerized using different methylmethacrylate (MMA) concentrations to evaluate their role in the antibacterial activity shown by NPs. Clinical strains of Staphylococcus aureus, S. epidermidis, S. lugdunensis and Enterococcus faecalis were used to assess antibacterial activity. The minimal inhibitory concentration (MIC) was determined at the different concentrations of NPs to appraise antibacterial activity. The cytotoxic effects of the NPs anchored with DMAEMA were determined in NIH3T3 mouse fibroblast cultures by MTT assays. All the employed NPs were effective against the studied bacterial strains, although increasing concentrations of the MMA added during the synthesis process diminished these effects without altering toxicity in cell cultures. To conclude, more studies with other copolymers are necessary to improve the antibacterial effects of NPs anchored with DMAEMA.

Original languageEnglish
Article number533
Issue number3
StatePublished - 7 Mar 2023
Externally publishedYes

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  • MMA
  • antibacterial activity
  • nanoparticles


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