Metal implants and modulation of the endothelial phenotype: In vitro studies

C. James Kirkpatrick, Ronald E. Unger, Roman Tsaryk, Fernando Bittinger, Kirsten Peters

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


It is a significant observation that the negative effects of components of CoCr alloy, whether ions, NPs or bulk material, on EC are much more marked than the effects of cpTi and Ti alloys. These experiments were carried out using metal concentrations below the overtly toxic range. The parameters studied with microvascular EC were relevant for inflammation and repair processes and the reaction patterns correlate well with the comparison of clinical performance, in which Ti is generally much more biocompatible in the implant situation than CoCr alloys. Our studies suggest that most of these negative effects appear to be due to Co 2+ ion formation, which markedly inhibits angiogenesis and thus could make a major contribution to reduced peri-implant healing.

Original languageEnglish
Title of host publication8th World Biomaterials Congress 2008
Number of pages1
StatePublished - 2008
Externally publishedYes
Event8th World Biomaterials Congress 2008, WBC 2008 - Amsterdam, Netherlands
Duration: 28 May 20081 Jun 2008

Publication series

Name8th World Biomaterials Congress 2008


Conference8th World Biomaterials Congress 2008, WBC 2008


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