TY - GEN
T1 - Metal implants and modulation of the endothelial phenotype
T2 - 8th World Biomaterials Congress 2008, WBC 2008
AU - Kirkpatrick, C. James
AU - Unger, Ronald E.
AU - Tsaryk, Roman
AU - Bittinger, Fernando
AU - Peters, Kirsten
PY - 2008
Y1 - 2008
N2 - It is a significant observation that the negative effects of components of CoCr alloy, whether ions, NPs or bulk material, on EC are much more marked than the effects of cpTi and Ti alloys. These experiments were carried out using metal concentrations below the overtly toxic range. The parameters studied with microvascular EC were relevant for inflammation and repair processes and the reaction patterns correlate well with the comparison of clinical performance, in which Ti is generally much more biocompatible in the implant situation than CoCr alloys. Our studies suggest that most of these negative effects appear to be due to Co 2+ ion formation, which markedly inhibits angiogenesis and thus could make a major contribution to reduced peri-implant healing.
AB - It is a significant observation that the negative effects of components of CoCr alloy, whether ions, NPs or bulk material, on EC are much more marked than the effects of cpTi and Ti alloys. These experiments were carried out using metal concentrations below the overtly toxic range. The parameters studied with microvascular EC were relevant for inflammation and repair processes and the reaction patterns correlate well with the comparison of clinical performance, in which Ti is generally much more biocompatible in the implant situation than CoCr alloys. Our studies suggest that most of these negative effects appear to be due to Co 2+ ion formation, which markedly inhibits angiogenesis and thus could make a major contribution to reduced peri-implant healing.
UR - http://www.scopus.com/inward/record.url?scp=84869031122&partnerID=8YFLogxK
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AN - SCOPUS:84869031122
SN - 9781615670802
T3 - 8th World Biomaterials Congress 2008
SP - 1645
BT - 8th World Biomaterials Congress 2008
Y2 - 28 May 2008 through 1 June 2008
ER -