Metabolic disposition and elimination studies of a radiolabelled biodegradable polymeric implant in the rat brain

Abraham J. Domb; M. Rock; J. Schwartz; C. Perkin; G. Yipchuk; B. Broxup; J. G. Villemure

doi:10.1016/0142-9612(94)90166-x

Metabolic disposition and elimination studies of a radiolabelled biodegradable polymeric implant in the rat brain

Abraham J. Domb, M. Rock, J. Schwartz, C. Perkin, G. Yipchuk, B. Broxup, J. G. Villemure

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Abstract

The metabolic disposition and elimination process of the anhydride co-polymer poly[1,3-bis(p-carboxyphenoxypropane): sebacic acid] 20:80 [P(CPP:SA)20:80] implanted in the rat brain was studied. Two polymers were prepared, one with [^14C]SA and unlabelled CPP, and the other co-polymer with [¹⁴C]CPP and unlabelled SA. With these two polymers we were able to study the metabolic disposition of each monomer after polymer degradation. Polymer wafers loaded with AJ,AJ-bis(2-chloroethyl)-JV-nitrosourea or without the drug were implanted in the rat brain. For the rats implanted with the [¹⁴C]SA-labelled polymer, approximately 40% of the radioactivity was found in the expired CO₂, 10% in the urine, about 2% in the faeces and about 10% remained in the device 7d after implantation. On the other hand, only 4% of the [¹⁴C]CPP monomer was eliminated by urine and faeces during this period. The drug-loaded polymer degraded faster than the blank polymer. This study supports the theory that the polymer is a biodegradable material that can be used for the direct and specific delivery of drugs into a targeted organ and can provide continued release of drugs over a period of time. Biomaterials (1994) 15, (9) 681-688.

Original language	English
Pages (from-to)	681-688
Number of pages	8
Journal	Biomaterials
Volume	15
Issue number	9
DOIs	https://doi.org/10.1016/0142-9612(94)90166-x
State	Published - Jul 1994
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported in part by NIH grant 5UOlCA52875-01. The authors would like to thank C. Mitoma and S. Rhee (Stanford Research Institute, Menlo Park, CA, USA) for the synthesis of the radio-active polymers, and M. Green and C. Clow from Nova for their help.

Funding

This study was supported in part by NIH grant 5UOlCA52875-01. The authors would like to thank C. Mitoma and S. Rhee (Stanford Research Institute, Menlo Park, CA, USA) for the synthesis of the radio-active polymers, and M. Green and C. Clow from Nova for their help.

Funders	Funder number
National Institutes of Health	5UOlCA52875-01
National Cancer Institute	U01CA052875

Keywords

Polyanhydrides
brain cancer
polymer elimination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0142-9612(94)90166-x

Cite this

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title = "Metabolic disposition and elimination studies of a radiolabelled biodegradable polymeric implant in the rat brain",

abstract = "The metabolic disposition and elimination process of the anhydride co-polymer poly[1,3-bis(p-carboxyphenoxypropane): sebacic acid] 20:80 [P(CPP:SA)20:80] implanted in the rat brain was studied. Two polymers were prepared, one with [14C]SA and unlabelled CPP, and the other co-polymer with [14C]CPP and unlabelled SA. With these two polymers we were able to study the metabolic disposition of each monomer after polymer degradation. Polymer wafers loaded with AJ,AJ-bis(2-chloroethyl)-JV-nitrosourea or without the drug were implanted in the rat brain. For the rats implanted with the [14C]SA-labelled polymer, approximately 40% of the radioactivity was found in the expired CO2, 10% in the urine, about 2% in the faeces and about 10% remained in the device 7d after implantation. On the other hand, only 4% of the [14C]CPP monomer was eliminated by urine and faeces during this period. The drug-loaded polymer degraded faster than the blank polymer. This study supports the theory that the polymer is a biodegradable material that can be used for the direct and specific delivery of drugs into a targeted organ and can provide continued release of drugs over a period of time. Biomaterials (1994) 15, (9) 681-688.",

keywords = "Polyanhydrides, brain cancer, polymer elimination",

author = "Domb, {Abraham J.} and M. Rock and J. Schwartz and C. Perkin and G. Yipchuk and B. Broxup and Villemure, {J. G.}",

note = "Funding Information: This study was supported in part by NIH grant 5UOlCA52875-01. The authors would like to thank C. Mitoma and S. Rhee (Stanford Research Institute, Menlo Park, CA, USA) for the synthesis of the radio-active polymers, and M. Green and C. Clow from Nova for their help.",

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AU - Domb, Abraham J.

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AU - Schwartz, J.

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AU - Yipchuk, G.

AU - Broxup, B.

AU - Villemure, J. G.

N1 - Funding Information: This study was supported in part by NIH grant 5UOlCA52875-01. The authors would like to thank C. Mitoma and S. Rhee (Stanford Research Institute, Menlo Park, CA, USA) for the synthesis of the radio-active polymers, and M. Green and C. Clow from Nova for their help.

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N2 - The metabolic disposition and elimination process of the anhydride co-polymer poly[1,3-bis(p-carboxyphenoxypropane): sebacic acid] 20:80 [P(CPP:SA)20:80] implanted in the rat brain was studied. Two polymers were prepared, one with [14C]SA and unlabelled CPP, and the other co-polymer with [14C]CPP and unlabelled SA. With these two polymers we were able to study the metabolic disposition of each monomer after polymer degradation. Polymer wafers loaded with AJ,AJ-bis(2-chloroethyl)-JV-nitrosourea or without the drug were implanted in the rat brain. For the rats implanted with the [14C]SA-labelled polymer, approximately 40% of the radioactivity was found in the expired CO2, 10% in the urine, about 2% in the faeces and about 10% remained in the device 7d after implantation. On the other hand, only 4% of the [14C]CPP monomer was eliminated by urine and faeces during this period. The drug-loaded polymer degraded faster than the blank polymer. This study supports the theory that the polymer is a biodegradable material that can be used for the direct and specific delivery of drugs into a targeted organ and can provide continued release of drugs over a period of time. Biomaterials (1994) 15, (9) 681-688.

AB - The metabolic disposition and elimination process of the anhydride co-polymer poly[1,3-bis(p-carboxyphenoxypropane): sebacic acid] 20:80 [P(CPP:SA)20:80] implanted in the rat brain was studied. Two polymers were prepared, one with [14C]SA and unlabelled CPP, and the other co-polymer with [14C]CPP and unlabelled SA. With these two polymers we were able to study the metabolic disposition of each monomer after polymer degradation. Polymer wafers loaded with AJ,AJ-bis(2-chloroethyl)-JV-nitrosourea or without the drug were implanted in the rat brain. For the rats implanted with the [14C]SA-labelled polymer, approximately 40% of the radioactivity was found in the expired CO2, 10% in the urine, about 2% in the faeces and about 10% remained in the device 7d after implantation. On the other hand, only 4% of the [14C]CPP monomer was eliminated by urine and faeces during this period. The drug-loaded polymer degraded faster than the blank polymer. This study supports the theory that the polymer is a biodegradable material that can be used for the direct and specific delivery of drugs into a targeted organ and can provide continued release of drugs over a period of time. Biomaterials (1994) 15, (9) 681-688.

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Metabolic disposition and elimination studies of a radiolabelled biodegradable polymeric implant in the rat brain

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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