Metabolic disposition and elimination studies of a radiolabelled biodegradable polymeric implant in the rat brain

Abraham J. Domb, M. Rock, J. Schwartz, C. Perkin, G. Yipchuk, B. Broxup, J. G. Villemure

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45 Scopus citations

Abstract

The metabolic disposition and elimination process of the anhydride co-polymer poly[1,3-bis(p-carboxyphenoxypropane): sebacic acid] 20:80 [P(CPP:SA)20:80] implanted in the rat brain was studied. Two polymers were prepared, one with [14C]SA and unlabelled CPP, and the other co-polymer with [14C]CPP and unlabelled SA. With these two polymers we were able to study the metabolic disposition of each monomer after polymer degradation. Polymer wafers loaded with AJ,AJ-bis(2-chloroethyl)-JV-nitrosourea or without the drug were implanted in the rat brain. For the rats implanted with the [14C]SA-labelled polymer, approximately 40% of the radioactivity was found in the expired CO2, 10% in the urine, about 2% in the faeces and about 10% remained in the device 7d after implantation. On the other hand, only 4% of the [14C]CPP monomer was eliminated by urine and faeces during this period. The drug-loaded polymer degraded faster than the blank polymer. This study supports the theory that the polymer is a biodegradable material that can be used for the direct and specific delivery of drugs into a targeted organ and can provide continued release of drugs over a period of time. Biomaterials (1994) 15, (9) 681-688.

Original languageEnglish
Pages (from-to)681-688
Number of pages8
JournalBiomaterials
Volume15
Issue number9
DOIs
StatePublished - Jul 1994
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported in part by NIH grant 5UOlCA52875-01. The authors would like to thank C. Mitoma and S. Rhee (Stanford Research Institute, Menlo Park, CA, USA) for the synthesis of the radio-active polymers, and M. Green and C. Clow from Nova for their help.

Keywords

  • Polyanhydrides
  • brain cancer
  • polymer elimination

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