Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

John R.B. Perry; Lisette Stolk; Nora Franceschini; Kathryn L. Lunetta; Guangju Zhai; Patrick F. McArdle; Albert V. Smith; Thor Aspelund; Stefania Bandinelli; Eric Boerwinkle; Lynn Cherkas; Gudny Eiriksdottir; Karol Estrada; Luigi Ferrucci; Aaron R. Folsom; Melissa Garcia; Vilmundur Gudnason; Albert Hofman; David Karasik; Douglas P. Kiel; Lenore J. Launer; Joyce Van Meurs; Michael A. Nalls; Fernando Rivadeneira; Alan R. Shuldiner; Andrew Singleton; Nicole Soranzo; Toshiko Tanaka; Jenny A. Visser; Michael N. Weedon; Scott G. Wilson; Vivian Zhuang; Elizabeth A. Streeten; Tamara B. Harris; Anna Murray; Tim D. Spector; Ellen W. Demerath; André G. Uitterlinden; Joanne M. Murabito

doi:10.1038/ng.386

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

John R.B. Perry, Lisette Stolk, Nora Franceschini, Kathryn L. Lunetta, Guangju Zhai, Patrick F. McArdle, Albert V. Smith, Thor Aspelund, Stefania Bandinelli, Eric Boerwinkle, Lynn Cherkas, Gudny Eiriksdottir, Karol Estrada, Luigi Ferrucci, Aaron R. Folsom, Melissa Garcia, Vilmundur Gudnason, Albert Hofman, David Karasik, Douglas P. KielLenore J. Launer, Joyce Van Meurs, Michael A. Nalls, Fernando Rivadeneira, Alan R. Shuldiner, Andrew Singleton, Nicole Soranzo, Toshiko Tanaka, Jenny A. Visser, Michael N. Weedon, Scott G. Wilson, Vivian Zhuang, Elizabeth A. Streeten, Tamara B. Harris, Anna Murray, Tim D. Spector, Ellen W. Demerath, André G. Uitterlinden, Joanne M. Murabito

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254 Scopus citations

Abstract

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10 9), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10 9), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.

Original language	English
Pages (from-to)	648-650
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	6
DOIs	https://doi.org/10.1038/ng.386
State	Published - Jun 2009
Externally published	Yes

Funding

Funders	Funder number
National Institutes of Health	M01RR016500, P30DK072488
National Institute on Aging	ZIAAG000965

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10.1038/ng.386

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Perry, J. R. B., Stolk, L., Franceschini, N., Lunetta, K. L., Zhai, G., McArdle, P. F., Smith, A. V., Aspelund, T., Bandinelli, S., Boerwinkle, E., Cherkas, L., Eiriksdottir, G., Estrada, K., Ferrucci, L., Folsom, A. R., Garcia, M., Gudnason, V., Hofman, A., Karasik, D., ... Murabito, J. M. (2009). Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nature Genetics, 41(6), 648-650. https://doi.org/10.1038/ng.386

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title = "Meta-analysis of genome-wide association data identifies two loci influencing age at menarche",

abstract = "We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10 9), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10 9), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.",

author = "Perry, {John R.B.} and Lisette Stolk and Nora Franceschini and Lunetta, {Kathryn L.} and Guangju Zhai and McArdle, {Patrick F.} and Smith, {Albert V.} and Thor Aspelund and Stefania Bandinelli and Eric Boerwinkle and Lynn Cherkas and Gudny Eiriksdottir and Karol Estrada and Luigi Ferrucci and Folsom, {Aaron R.} and Melissa Garcia and Vilmundur Gudnason and Albert Hofman and David Karasik and Kiel, {Douglas P.} and Launer, {Lenore J.} and {Van Meurs}, Joyce and Nalls, {Michael A.} and Fernando Rivadeneira and Shuldiner, {Alan R.} and Andrew Singleton and Nicole Soranzo and Toshiko Tanaka and Visser, {Jenny A.} and Weedon, {Michael N.} and Wilson, {Scott G.} and Vivian Zhuang and Streeten, {Elizabeth A.} and Harris, {Tamara B.} and Anna Murray and Spector, {Tim D.} and Demerath, {Ellen W.} and Uitterlinden, {Andr{\'e} G.} and Murabito, {Joanne M.}",

year = "2009",

month = jun,

doi = "10.1038/ng.386",

language = "אנגלית",

volume = "41",

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Perry, JRB, Stolk, L, Franceschini, N, Lunetta, KL, Zhai, G, McArdle, PF, Smith, AV, Aspelund, T, Bandinelli, S, Boerwinkle, E, Cherkas, L, Eiriksdottir, G, Estrada, K, Ferrucci, L, Folsom, AR, Garcia, M, Gudnason, V, Hofman, A, Karasik, D, Kiel, DP, Launer, LJ, Van Meurs, J, Nalls, MA, Rivadeneira, F, Shuldiner, AR, Singleton, A, Soranzo, N, Tanaka, T, Visser, JA, Weedon, MN, Wilson, SG, Zhuang, V, Streeten, EA, Harris, TB, Murray, A, Spector, TD, Demerath, EW, Uitterlinden, AG & Murabito, JM 2009, 'Meta-analysis of genome-wide association data identifies two loci influencing age at menarche', Nature Genetics, vol. 41, no. 6, pp. 648-650. https://doi.org/10.1038/ng.386

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AU - Perry, John R.B.

AU - Stolk, Lisette

AU - Franceschini, Nora

AU - Lunetta, Kathryn L.

AU - Zhai, Guangju

AU - McArdle, Patrick F.

AU - Smith, Albert V.

AU - Aspelund, Thor

AU - Bandinelli, Stefania

AU - Boerwinkle, Eric

AU - Cherkas, Lynn

AU - Eiriksdottir, Gudny

AU - Estrada, Karol

AU - Ferrucci, Luigi

AU - Folsom, Aaron R.

AU - Garcia, Melissa

AU - Gudnason, Vilmundur

AU - Hofman, Albert

AU - Karasik, David

AU - Kiel, Douglas P.

AU - Launer, Lenore J.

AU - Van Meurs, Joyce

AU - Nalls, Michael A.

AU - Rivadeneira, Fernando

AU - Shuldiner, Alan R.

AU - Singleton, Andrew

AU - Soranzo, Nicole

AU - Tanaka, Toshiko

AU - Visser, Jenny A.

AU - Weedon, Michael N.

AU - Wilson, Scott G.

AU - Zhuang, Vivian

AU - Streeten, Elizabeth A.

AU - Harris, Tamara B.

AU - Murray, Anna

AU - Spector, Tim D.

AU - Demerath, Ellen W.

AU - Uitterlinden, André G.

AU - Murabito, Joanne M.

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SP - 648

EP - 650

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

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