Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans

Gali H. Weissberger; Daniel A. Nation; Caroline P. Nguyen; Mark W. Bondi; S. Duke Han

doi:10.1016/j.neubiorev.2018.08.009

Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans

Gali H. Weissberger, Daniel A. Nation, Caroline P. Nguyen, Mark W. Bondi, S. Duke Han

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

The apolipoprotein (APOE) ε4 allele has been proposed as an example of an antagonistic pleiotropy gene, conferring a beneficial effect on cognition in early life and a detrimental impact on cognition during later years. However, findings on the cognitive associations of the ε4 allele in younger persons are mixed. This PRISMA conforming study aimed to investigate APOE genotype (e4/non-e4) associations across seven cognitive domains (intelligence/achievement, attention/working memory, executive functioning, memory, language, processing speed and visuospatial abilities) in younger humans using a meta-analytic approach. Of 689 records reviewed, 29 studies (34 data-points) were selected for the quantitative synthesis. Participants’ ages ranged from 2-40. Results showed that young ε4 carriers did not statistically differ from non-ε4 carriers across any cognitive domains. Overall, findings do not provide compelling support for an antagonistic pleiotropic effect of the ε4 allele across the lifespan.

Original language	English
Pages (from-to)	49-58
Number of pages	10
Journal	Neuroscience and Biobehavioral Reviews
Volume	94
DOIs	https://doi.org/10.1016/j.neubiorev.2018.08.009
State	Published - Nov 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

Funding

This work is supported by National Institute on Aging [grant number R01AG055430 ] awarded to SDH; and the Department of Family Medicine of the University of Southern California , as well as National Institute on Aging [grant numbers R21AG055034 , P01AG052350 , P50AG005142 ] and Alzheimer’s Association [grant number AARG-17-532905 ] awarded to DAN; National Institute on Aging [K24 AG026431 and R01 AG049810] to MWB; and the Department of Psychology, University of Southern California . Authors acknowledge the Department of Family Medicine of University of Southern California for support of this work.

Funders	Funder number
Department of Family Medicine of University of Southern California
Department of Family Medicine of the University of Southern California
National Institute on Aging	P01AG052350, P50AG005142, R01AG055430, R21AG055034
Alzheimer's Association	AARG-17-532905, R01 AG049810, K24 AG026431
University of Southern California

Keywords

Alzheimer's disease
Apolipoprotein E
Cognition
Executive functions
Neuropsychology
PRISMA

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10.1016/j.neubiorev.2018.08.009

Cite this

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title = "Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans",

abstract = "The apolipoprotein (APOE) ε4 allele has been proposed as an example of an antagonistic pleiotropy gene, conferring a beneficial effect on cognition in early life and a detrimental impact on cognition during later years. However, findings on the cognitive associations of the ε4 allele in younger persons are mixed. This PRISMA conforming study aimed to investigate APOE genotype (e4/non-e4) associations across seven cognitive domains (intelligence/achievement, attention/working memory, executive functioning, memory, language, processing speed and visuospatial abilities) in younger humans using a meta-analytic approach. Of 689 records reviewed, 29 studies (34 data-points) were selected for the quantitative synthesis. Participants{\textquoteright} ages ranged from 2-40. Results showed that young ε4 carriers did not statistically differ from non-ε4 carriers across any cognitive domains. Overall, findings do not provide compelling support for an antagonistic pleiotropic effect of the ε4 allele across the lifespan.",

keywords = "Alzheimer's disease, Apolipoprotein E, Cognition, Executive functions, Neuropsychology, PRISMA",

author = "Weissberger, {Gali H.} and Nation, {Daniel A.} and Nguyen, {Caroline P.} and Bondi, {Mark W.} and Han, {S. Duke}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

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doi = "10.1016/j.neubiorev.2018.08.009",

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AU - Nguyen, Caroline P.

AU - Bondi, Mark W.

AU - Han, S. Duke

PY - 2018/11

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KW - Executive functions

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Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans

Abstract

Bibliographical note

Funding

Keywords

Access to Document

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