TY - JOUR
T1 - Meta-analyses of dietary fats and mammary neoplasms in rodent experiments
AU - Fay, Michael P.
AU - Freedman, Laurence S.
PY - 1997
Y1 - 1997
N2 - We review two meta-analyses of experiments on dietary fat and mammary tumor incidence in rodents, emphasizing a recent meta-analysis on the effects of different types of dietary fatty acids. This analysis shows that n-6 polyunsaturated fatty acids most strongly enhance mammary tumors in rodents, and saturated fats also enhance these tumors but less strongly. Further, the analysis shows that energy restriction protects against mammary tumors. We show that these results agree qualitatively with estimates of effects on human breast cancer derived from international correlations.
AB - We review two meta-analyses of experiments on dietary fat and mammary tumor incidence in rodents, emphasizing a recent meta-analysis on the effects of different types of dietary fatty acids. This analysis shows that n-6 polyunsaturated fatty acids most strongly enhance mammary tumors in rodents, and saturated fats also enhance these tumors but less strongly. Further, the analysis shows that energy restriction protects against mammary tumors. We show that these results agree qualitatively with estimates of effects on human breast cancer derived from international correlations.
KW - Breast cancer
KW - Monounsaturated fats
KW - Saturated fats
KW - n-3 Fatty acids
KW - n-6 Fatty acids
UR - http://www.scopus.com/inward/record.url?scp=0031444836&partnerID=8YFLogxK
U2 - 10.1023/a:1005927503865
DO - 10.1023/a:1005927503865
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C2 - 9478276
AN - SCOPUS:0031444836
SN - 0167-6806
VL - 46
SP - 215
EP - 223
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 2-3
ER -
