Meta-analyses of dietary fats and mammary neoplasms in rodent experiments

Michael P. Fay, Laurence S. Freedman

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

We review two meta-analyses of experiments on dietary fat and mammary tumor incidence in rodents, emphasizing a recent meta-analysis on the effects of different types of dietary fatty acids. This analysis shows that n-6 polyunsaturated fatty acids most strongly enhance mammary tumors in rodents, and saturated fats also enhance these tumors but less strongly. Further, the analysis shows that energy restriction protects against mammary tumors. We show that these results agree qualitatively with estimates of effects on human breast cancer derived from international correlations.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalBreast Cancer Research and Treatment
Volume46
Issue number2-3
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • Breast cancer
  • Monounsaturated fats
  • Saturated fats
  • n-3 Fatty acids
  • n-6 Fatty acids

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