Mesalamine-induced granulomatous hepatitis

Marius Braun; Gerald M. Fraser; Margareta Kunin; Francis Salamon; Ran Tur Kaspa

doi:10.1016/s0002-9270(99)00301-9

Mesalamine-induced granulomatous hepatitis

Marius Braun
, Gerald M. Fraser
, Margareta Kunin
, Francis Salamon
, Ran Tur Kaspa

Rabin Medical Center Israel

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

A 42-yr-old man with ulcerative colitis was admitted for investigation of prolonged fever associated with cholestatic liver tests. Endoscopic retrograde cholangiopancreatography demonstrated a normal biliary tree, and liver biopsy showed granulomata. A clinical diagnosis of drug-induced granulomatous hepatitis was established as the symptoms disappeared after cessation of mesalamine therapy and recurred on rechallenge. Although the differential diagnosis of fever and hepatitis in patients with inflammatory bowel disease is wide, in this case mesalamine is the most likely cause.

Original language	English
Pages (from-to)	1973-1974
Number of pages	2
Journal	American Journal of Gastroenterology
Volume	94
Issue number	7
DOIs	https://doi.org/10.1016/s0002-9270(99)00301-9
State	Published - Jul 1999
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/s0002-9270(99)00301-9

Cite this

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title = "Mesalamine-induced granulomatous hepatitis",

abstract = "A 42-yr-old man with ulcerative colitis was admitted for investigation of prolonged fever associated with cholestatic liver tests. Endoscopic retrograde cholangiopancreatography demonstrated a normal biliary tree, and liver biopsy showed granulomata. A clinical diagnosis of drug-induced granulomatous hepatitis was established as the symptoms disappeared after cessation of mesalamine therapy and recurred on rechallenge. Although the differential diagnosis of fever and hepatitis in patients with inflammatory bowel disease is wide, in this case mesalamine is the most likely cause.",

author = "Marius Braun and Fraser, \{Gerald M.\} and Margareta Kunin and Francis Salamon and Kaspa, \{Ran Tur\}",

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AU - Fraser, Gerald M.

AU - Kunin, Margareta

AU - Salamon, Francis

AU - Kaspa, Ran Tur

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N2 - A 42-yr-old man with ulcerative colitis was admitted for investigation of prolonged fever associated with cholestatic liver tests. Endoscopic retrograde cholangiopancreatography demonstrated a normal biliary tree, and liver biopsy showed granulomata. A clinical diagnosis of drug-induced granulomatous hepatitis was established as the symptoms disappeared after cessation of mesalamine therapy and recurred on rechallenge. Although the differential diagnosis of fever and hepatitis in patients with inflammatory bowel disease is wide, in this case mesalamine is the most likely cause.

AB - A 42-yr-old man with ulcerative colitis was admitted for investigation of prolonged fever associated with cholestatic liver tests. Endoscopic retrograde cholangiopancreatography demonstrated a normal biliary tree, and liver biopsy showed granulomata. A clinical diagnosis of drug-induced granulomatous hepatitis was established as the symptoms disappeared after cessation of mesalamine therapy and recurred on rechallenge. Although the differential diagnosis of fever and hepatitis in patients with inflammatory bowel disease is wide, in this case mesalamine is the most likely cause.

UR - https://www.scopus.com/pages/publications/0033051599

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JO - American Journal of Gastroenterology

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Mesalamine-induced granulomatous hepatitis

Abstract

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