Meningiomas in the elderly, the surgical benefit and a new scoring system

Or Cohen-Inbar, Jean F. Soustiel, Menashe Zaaroor

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Objective: The purpose of the study was to define and identify prognostic indicators within an elderly population of patients suffering from intracranial meningiomas. The clinical presentation of the patient with meningioma is diverse, manifesting as a different clinical entity in the elderly patient compared to a similar type of tumor in a young patient. Methods: Two hundred fifty patients aged over 65 years admitted to RAMBAM Medical Center with meningiomas from 1995-2005 were characterized. We report the presenting symptoms, chronic illnesses, perioperative and long-term follow-up results for a 5-year period. Results: Based on univariate and multivariate analysis, significant prognostic indicators were identified and were implemented into a new geriatric scoring system (GSS) including tumor size and location, peritumoral edema, neurological deficits, Karnofsky score (Clancey J Neurosci Nurs 27:220, 1995; Crooks et al. J Gerontol 46:M139-M144, 1991), and associated diabetes, hypertension or lung disease. Seven outcome parameters were retrospectively tested using the scoring system, namely mortality, Barthel Index score (Mahoney and Barthel Md State Med J 14:61-65, 1965), Karnofsky score and consciousness expressed by the Glasgow Coma Scale score (Jennett and Bond Lancet 1:480-484, 1975) 5 years after surgery, as well as recurrence within and beyond 12 months. Age proved to inversely correlate with outcome. Morbidity and mortality were significantly lower in women. The extent of surgical resection (Simpson J Neurol Neurosurg Psychiatry 20:22-39, 1957) had no influence on functional outcome, although radical resection was associated with significantly lower mortality. Generally, a GSS score higher than 14 was associated with a significantly more favorable outcome. Conclusion: The present results suggest that common experience-based considerations may be optimized and implemented into a simple scoring system that in turn may allow for outcome prediction and evidence-based decision making.

Original languageEnglish
Pages (from-to)87-97
Number of pages11
JournalActa Neurochirurgica
Volume152
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Bibliographical note

Funding Information:
No financial support was received anytime during the generation of this submission.

Keywords

  • Elderly
  • Evidence-based meningioma surgical treatment
  • GSS score
  • Meningioma
  • Prognosis

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