Memory-guided saccadic eye movements: Effects of cerebellar disease

Adriana A. Kori; Vallabh E. Das; Ari Z. Zivotofsky; R. John Leigh

doi:10.1016/S0042-6989(98)00026-1

Memory-guided saccadic eye movements: Effects of cerebellar disease

Adriana A. Kori, Vallabh E. Das, Ari Z. Zivotofsky, R. John Leigh

Case Western Reserve University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We compared the accuracy of oblique, memory-guided saccades if the eye is stationary or moves horizontally during the memory period. We studied 11 patients with cerebellar disease and 11 age-matched control subjects. Normal subjects showed similar accuracy of saccades for both conditions. In contrast, all patients showed greater errors if the eye moved horizontally during the memory period; however, errors of both vertical and horizontal components of memory-guided saccades were similar. Thus, inaccuracy of memory-guided saccades could not be simply attributed to failure to internally monitor change in horizontal gaze during the memory period. Instead, we propose that the greater saccadic errors which occurred when gaze changed during the memory period reflected a disruption of predictive mechanisms governing eye movements.

Original language	English
Pages (from-to)	3181-3192
Number of pages	12
Journal	Vision Research
Volume	38
Issue number	20
DOIs	https://doi.org/10.1016/S0042-6989(98)00026-1
State	Published - Oct 1998
Externally published	Yes

Bibliographical note

Funding Information:
Supported by USPHS grant EY06717, the Office of Research and Development, Medical Research Service, Department of Veterans Affairs, and the Evenor Armington Fund (to R.J. Leigh). We are grateful to Drs Klaus Rottach for help with computer programs, and to O. Zaidat for referring patients 1–3, and to Drs John S. Stahl and Lea Averbuch-Heller for critically reviewing the manuscript.

Keywords

Cerebellum
Eye movements
Memory
Saccades

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10.1016/S0042-6989(98)00026-1

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title = "Memory-guided saccadic eye movements: Effects of cerebellar disease",

abstract = "We compared the accuracy of oblique, memory-guided saccades if the eye is stationary or moves horizontally during the memory period. We studied 11 patients with cerebellar disease and 11 age-matched control subjects. Normal subjects showed similar accuracy of saccades for both conditions. In contrast, all patients showed greater errors if the eye moved horizontally during the memory period; however, errors of both vertical and horizontal components of memory-guided saccades were similar. Thus, inaccuracy of memory-guided saccades could not be simply attributed to failure to internally monitor change in horizontal gaze during the memory period. Instead, we propose that the greater saccadic errors which occurred when gaze changed during the memory period reflected a disruption of predictive mechanisms governing eye movements.",

keywords = "Cerebellum, Eye movements, Memory, Saccades",

author = "Kori, {Adriana A.} and Das, {Vallabh E.} and Zivotofsky, {Ari Z.} and Leigh, {R. John}",

note = "Funding Information: Supported by USPHS grant EY06717, the Office of Research and Development, Medical Research Service, Department of Veterans Affairs, and the Evenor Armington Fund (to R.J. Leigh). We are grateful to Drs Klaus Rottach for help with computer programs, and to O. Zaidat for referring patients 1–3, and to Drs John S. Stahl and Lea Averbuch-Heller for critically reviewing the manuscript.",

year = "1998",

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AU - Kori, Adriana A.

AU - Das, Vallabh E.

AU - Zivotofsky, Ari Z.

AU - Leigh, R. John

N1 - Funding Information: Supported by USPHS grant EY06717, the Office of Research and Development, Medical Research Service, Department of Veterans Affairs, and the Evenor Armington Fund (to R.J. Leigh). We are grateful to Drs Klaus Rottach for help with computer programs, and to O. Zaidat for referring patients 1–3, and to Drs John S. Stahl and Lea Averbuch-Heller for critically reviewing the manuscript.

PY - 1998/10

Y1 - 1998/10

N2 - We compared the accuracy of oblique, memory-guided saccades if the eye is stationary or moves horizontally during the memory period. We studied 11 patients with cerebellar disease and 11 age-matched control subjects. Normal subjects showed similar accuracy of saccades for both conditions. In contrast, all patients showed greater errors if the eye moved horizontally during the memory period; however, errors of both vertical and horizontal components of memory-guided saccades were similar. Thus, inaccuracy of memory-guided saccades could not be simply attributed to failure to internally monitor change in horizontal gaze during the memory period. Instead, we propose that the greater saccadic errors which occurred when gaze changed during the memory period reflected a disruption of predictive mechanisms governing eye movements.

AB - We compared the accuracy of oblique, memory-guided saccades if the eye is stationary or moves horizontally during the memory period. We studied 11 patients with cerebellar disease and 11 age-matched control subjects. Normal subjects showed similar accuracy of saccades for both conditions. In contrast, all patients showed greater errors if the eye moved horizontally during the memory period; however, errors of both vertical and horizontal components of memory-guided saccades were similar. Thus, inaccuracy of memory-guided saccades could not be simply attributed to failure to internally monitor change in horizontal gaze during the memory period. Instead, we propose that the greater saccadic errors which occurred when gaze changed during the memory period reflected a disruption of predictive mechanisms governing eye movements.

KW - Cerebellum

KW - Eye movements

KW - Memory

KW - Saccades

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Memory-guided saccadic eye movements: Effects of cerebellar disease

Abstract

Bibliographical note

Keywords

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