Mechano-electric feedback effects in a three-dimensional (3D) model of the contracting cardiac ventricle

Ani Amar, Sharon Zlochiver, Ofer Barnea

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Mechano-electric feedback affects the electrophysiological and mechanical function of the heart and the cellular, tissue, and organ properties. To determine the main factors that contribute to this effect, this study investigated the changes in the action potential characteristics of the ventricle during contraction. A model of stretch-activated channels was incorporated into a three-dimensional multiscale model of the contracting ventricle to assess the effect of different preload lengths on the electrophysiological behavior. The model describes the initiation and propagation of the electrical impulse, as well as the passive (stretch) and active (contraction) changes in the cardiac mechanics. Simulations were performed to quantify the relationship between the cellular activation and recovery patterns as well as the action potential durations at different preload lengths in normal and heart failure pathological conditions. The simulation results showed that heart failure significantly affected the excitation propagation parameters compared to normal condition. The results showed that the mechano-electrical feedback effects appear to be most important in failing hearts with low ejection fraction.

Original languageEnglish
Article numbere0191238
JournalPLoS ONE
Issue number1
StatePublished - Jan 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 Amar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Dive into the research topics of 'Mechano-electric feedback effects in a three-dimensional (3D) model of the contracting cardiac ventricle'. Together they form a unique fingerprint.

Cite this