Mechanistically orthogonal radical strategies converging on programmable site-selective halogenation of quinoxalinones

Chidananda Biswal; Pravat Nayek; Sandeepan Maity; Prasenjit Mal

doi:10.1039/d6cc01927g

Mechanistically orthogonal radical strategies converging on programmable site-selective halogenation of quinoxalinones

Chidananda Biswal
, Pravat Nayek
, Sandeepan Maity
, Prasenjit Mal

Homi Bhabha National Institute
C. V. Raman College of Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

We report reagent-programmed C₃-, C₆-, and C₇-halogenation of quinoxalinones via two orthogonal radical pathways converging on identical products. A sunlight-driven PDI photoredox system activates inorganic halides, while a moisture assisted N-halosuccinimide radical chain yields 7-halodihydroquinoxalin-2,3-diones with high selectivity and 6,7-dihalo products at higher halide loadings.

Original language	English
Pages (from-to)	12157-12161
Number of pages	5
Journal	Chemical Communications
Volume	62
Issue number	48
DOIs	https://doi.org/10.1039/d6cc01927g
State	Published - 23 Jun 2026
Externally published	Yes

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Publisher Copyright:
This journal is © The Royal Society of Chemistry, 2026.

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abstract = "We report reagent-programmed C3-, C6-, and C7-halogenation of quinoxalinones via two orthogonal radical pathways converging on identical products. A sunlight-driven PDI photoredox system activates inorganic halides, while a moisture assisted N-halosuccinimide radical chain yields 7-halodihydroquinoxalin-2,3-diones with high selectivity and 6,7-dihalo products at higher halide loadings.",

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AU - Maity, Sandeepan

AU - Mal, Prasenjit

N1 - Publisher Copyright: This journal is © The Royal Society of Chemistry, 2026.

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Y1 - 2026/6/23

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AB - We report reagent-programmed C3-, C6-, and C7-halogenation of quinoxalinones via two orthogonal radical pathways converging on identical products. A sunlight-driven PDI photoredox system activates inorganic halides, while a moisture assisted N-halosuccinimide radical chain yields 7-halodihydroquinoxalin-2,3-diones with high selectivity and 6,7-dihalo products at higher halide loadings.

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Mechanistically orthogonal radical strategies converging on programmable site-selective halogenation of quinoxalinones

Abstract

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