Mechanistic description of spontaneous loss of memory persistent activity based on neuronal synaptic strength

Hillel Sanhedrai, Shlomo Havlin, Hila Dvir

Research output: Contribution to journalArticlepeer-review


Persistent neural activity associated with working memory (WM) lasts for a limited time duration. Current theories suggest that its termination is actively obtained via inhibitory currents, and there is currently no theory regarding the possibility of a passive memory-loss mechanism that terminates memory persistent activity. Here, we develop an analytical-framework, based on synaptic strength, and show via simulations and fitting to wet-lab experiments, that passive memory-loss might be a result of an ionic-current long-term plateau, i.e., very slow reduction of memory followed by abrupt loss. We describe analytically the plateau, when the memory state is just below criticality. These results, including the plateau, are supported by experiments performed on rats. Moreover, we show that even just above criticality, forgetfulness can occur due to neuronal noise with ionic-current fluctuations, yielding a plateau, representing memory with very slow decay, and eventually a fast memory decay. Our results could have implications for developing new medications, targeted against memory impairments, through modifying neuronal noise.

Original languageEnglish
Article numbere23949
Issue number1
StatePublished - 15 Jan 2024

Bibliographical note

Publisher Copyright:
© 2023 The Authors


H.Sanhedrai acknowledges the support of the Presidential Fellowship of Bar-Ilan University, Israel, and the Mordecai and Monique Katz Graduate Fellowship Program. We thank the Israel Science Foundation (grant number 2830/23 ), the Binational Israel-China Science Foundation (grant number 3132/19 ), the European Union under the Horizon Europe grant OMINO (grant number 101086321 ).

FundersFunder number
Binational Israel-China Science Foundation3132/19
HORIZON EUROPE Framework Programme101086321
European Commission
Bar-Ilan University
Israel Science Foundation2830/23


    Dive into the research topics of 'Mechanistic description of spontaneous loss of memory persistent activity based on neuronal synaptic strength'. Together they form a unique fingerprint.

    Cite this