Mechanisms of cooperativity underlying sequence-independent β-sheet formation

Chinlin Guo, Margaret S. Cheung, Herbert Levine, David A. Kessler

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The mechanism of β-sheet cooperativity without side-chain interactions, at the different choice of the H-bond potential, was explored. The results indicate that in the absence of hydrophobic clustering, the β-sheet cooperativity arises from a combination of structural factors, protein de/solvation effects, and the system topology.

Original languageEnglish
Pages (from-to)4353-4365
Number of pages13
JournalJournal of Chemical Physics
Volume116
Issue number10
DOIs
StatePublished - 8 Mar 2002

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