Mechanism of reaction of peroxomethyl radicals with copper(II)(glycine) 2 and copper(II)(glycylglycylglycine) in aqueous solutions

Corin Mansano-Weiss, Alexandra Masarwa, Haim Cohen, Dan Meyerstein

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7 Scopus citations

Abstract

The reactions of •O2CH3 radicals with Cu II(glycine)2 and CuII(GGG), GGG = glycylglycylglycine, in aqueous solutions were studied. The results demonstrate that the peroxyl radicals oxidize the copper complexes forming relatively stable intermediates of the type LmCuIII-OOCH3. These intermediates decompose via oxidation of the ligands glycine and GGG, respectively. Substituents on the alkyl of the peroxyl radical affect somewhat the kinetics of reaction but not the mechanism of oxidation. It is suggested that analogous reactions are probably contributing to the radical-induced deleterious biological processes.

Original languageEnglish
Pages (from-to)2199-2206
Number of pages8
JournalInorganica Chimica Acta
Volume358
Issue number7
DOIs
StatePublished - 15 Apr 2005
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported in part by grants from the Israel Science Foundation and from the Budgeting and Planning Committee of The Council of Higher Education and the Israel Atomic Energy Commission. D.M. thanks the Alexander von Humboldt Foundation for support and Mrs. Irene Evens for her ongoing interest and support.

Keywords

  • Biological ligands
  • Copper complexes
  • Peroxyl radicals

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