Mechanism of cysteine protease inactivation by peptidyl epoxides

Keyphrases

• Cysteine Protease 100%
• Epoxides 100%
• Protease Inactivation 100%
• Alkylation 50%
• Active Sites 16%
• Order of Magnitude 16%
• Benzyl 16%
• Aqueous Media 16%
• All Levels 16%
• Enzymatic Activity 16%
• Cysteine 16%
• Thiols 16%
• Concentration-dependent 16%
• Native Conformation 16%
• Dialysis 16%
• Cysteine Protease Inhibitor 16%
• Cathepsin B 16%
• Inactivation Mechanism 16%
• Mechanistic Implication 16%
• Lack of Recovery 16%
• Mechanism-based Inhibition 16%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Cysteine Protease 100%
• Alkylation 50%
• Active Site 25%
• Conformation 25%
• Thiol 25%
• Cysteine 25%
• Protease Inhibitor 25%
• Enzyme Activity 25%
• Cathepsin B 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Epoxide 100%
• Cysteine Proteinase 100%
• Cysteine 16%
• Thiol 16%
• Proteinase Inhibitor 16%
• Cathepsin B 16%