Mean Platelet Volume in Pemphigus Vulgaris

Khalaf Kridin, Wesal Shihade, Shira Zelber-Sagi

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. The mean platelet volume (MPV) is an index of platelet activation reported to be influenced by inflammation. We investigated the MPV in patients with PV relative to controls. This case–control study included 160 patients with PV and 640 age- and sex-matched controls. The MPV, platelet count, and other inflammatory parameters were measured for all study participants. A significantly decreased MPV was observed in patients with PV compared with controls, 9.1 (1.5) fL versus 10.3 (1.4) fL, P <.001. A significant negative association between MPV and PV was demonstrated in multivariate analysis (odds ratio, 0.59; 95% confidence interval, 0.51-0.68, P <.0001). Patients having PV with laryngeal involvement had significantly lower MPVs than those without involvement of the larynx, 8.81 (1.5) fL versus 9.32 (1.4) fL, P =.032. Disease activity (before and after treatment) does not affect the MPV. Patients with PV showed decreased MPV values compared to healthy controls. The MPV may be a feasible diagnostic marker in patients with PV.

Original languageEnglish
Pages (from-to)303-307
Number of pages5
Issue number4
StatePublished - 1 Apr 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017, © The Author(s) 2017.


  • inflammation
  • laryngeal involvement
  • mean platelet volume
  • pemphigus vulgaris
  • platelet


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