Abstract
Maternal nutritional, metabolic, and physiological states, as well as exposure to various environmental factors during conception, gestation, and lactation, have a fundamental role in the health programming of the offspring. Therefore, alterations affecting the maternal microbiota might indirectly influence fetal development. In addition, such alterations could be transmitted to the progeny at different stages of infant development (e.g., preconception, prenatal, or postnatal), thereby favoring the development of an altered microbiota in the neonate. Microbial changes of this kind have been linked to an increased risk of non-communicable diseases (NCDs), including obesity and metabolic syndrome, allergy-related problems, and diabetes. In this review, we summarize the relevance of the maternal microbiota to fetal–neonatal health programming, with a focus on maternal nutritional and metabolic states.
| Original language | English |
|---|---|
| Pages (from-to) | 735-744 |
| Number of pages | 10 |
| Journal | Trends in Endocrinology and Metabolism |
| Volume | 30 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2019 |
Bibliographical note
Publisher Copyright:© 2019 Elsevier Ltd
Funding
M.C.C. acknowledges the European Research Council under the European Union’s Horizon 2020 Research and Innovation Program (ERC starting grant, n° 639226 ). M.C. is supported by the Research Foundation Flanders (postdoctoral fellowship FWO-12R2717N and travel grant FWO-V436918N ). O.K. is supported by the Alon fellowship, the Carasso fellowship and grants funded by IBM , the Marie Curie International Reintegration Grant ( FP7-PEOPLE-2013-CIG-630956 ), the Israel Science Foundation ( 1001/16 ), the Minerva Foundation , the Israeli Ministry of Health ( 3-0000-10451 ), and the Canadian-Israel Health Initiative, jointly funded by the Canadian Institutes of Health Research , the Israel Science Foundation , the International Development Research Centre , Canada, and the Azrieli Foundation ( 2459/15 ). M.C.C. acknowledges the European Research Council under the European Union's Horizon 2020 Research and Innovation Program (ERC starting grant, n? 639226). M.C. is supported by the Research Foundation Flanders (postdoctoral fellowship FWO-12R2717N and travel grant FWO-V436918N). O.K. is supported by the Alon fellowship, the Carasso fellowship and grants funded by IBM, the Marie Curie International Reintegration Grant (FP7-PEOPLE-2013-CIG-630956), the Israel Science Foundation (1001/16), the Minerva Foundation, the Israeli Ministry of Health (3-0000-10451), and the Canadian-Israel Health Initiative, jointly funded by the Canadian Institutes of Health Research, the Israel Science Foundation, the International Development Research Centre, Canada, and the Azrieli Foundation (2459/15).
| Funders | Funder number |
|---|---|
| Canadian-Israel Health Initiative | |
| ERC starting | |
| European Union’s Horizon 2020 research and innovation program | |
| International Development Research Centre, Canada | |
| M.C.C. | |
| Marie Curie International Reintegration | |
| International Business Machines Corporation | FP7-PEOPLE-2013-CIG-630956 |
| Horizon 2020 Framework Programme | 639226 |
| Canadian Institutes of Health Research | |
| International Development Research Centre | |
| European Commission | |
| Minerva Foundation | |
| Fonds Wetenschappelijk Onderzoek | FWO-12R2717N, FWO-V436918N |
| Israel Science Foundation | 1001/16 |
| Azrieli Foundation | 2459/15 |
| Ministry of Health, State of Israel | 3-0000-10451 |
Keywords
- C-section
- antibiotic
- diabetes
- lactation
- microbiota
- neonatal health
- nutrition
- obesity
