Mammalian testis-determining factor SRY and the enigma of inherited human sex reversal: Frustrated induced fit in a bent protein-DNA complex

Keyphrases

• Protein-DNA Complex 100%
• Testicle 100%
• DNA Bending 100%
• Induced Fit 100%
• Sex Reversal 100%
• DNA Binding 66%
• Inherited mutation 66%
• Single-molecule Fluorescence Resonance Energy Transfer (smFRET) 66%
• Spermatogenesis 33%
• Downstream Targets 33%
• Dissociation 33%
• Transcriptional Regulation 33%
• Genetic Background 33%
• Protein Folding 33%
• Biophysical Properties 33%
• High Mobility Group Box 1 (HMGB1) 33%
• Energy Transfer Studies 33%
• Local Perturbation 33%
• Conformational Fluctuations 33%
• Gonadal Cells 33%
• Gonadal Dysgenesis 33%
• 1H NMR Studies 33%
• Variant Proteins 33%
• Sub-nanosecond 33%
• Type Studies 33%
• Mutation Sites 33%
• L-shaped Domain 33%
• Stopped-flow Fluorescence 33%
• Nonlocal Coupling 33%
• Partial Activation 33%
• Range Variation 33%
• Male Development 33%
• Bending Angle 33%
• Genetic Switch 33%
• SRY-box Transcription Factor 9 (SOX9) 33%

Biochemistry, Genetics and Molecular Biology

• DNA Bending 100%
• DNA Protein Complex 100%
• Testis Determining Factor 100%
• Fluorescence Resonance Energy Transfer 66%
• DNA Binding 66%
• Genetics 33%
• Wild Type 33%
• Spermatogenesis 33%
• Protein Folding 33%
• Genetic Background 33%
• High-Mobility Group 33%