Magnetoencephalographic correlates of mood and reward dynamics in human adolescents

Lucrezia Liuzzi, Katharine K. Chang, Charles Zheng, Hanna Keren, Dipta Saha, Dylan M. Nielson, Argyris Stringaris

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Despite its omnipresence in everyday interactions and its importance for mental health, mood and its neuronal underpinnings are poorly understood. Computational models can help identify parameters affecting self-reported mood during mood induction tasks. Here, we test if computationally modeled dynamics of self-reported mood during monetary gambling can be used to identify trial-by-trial variations in neuronal activity. To this end, we shifted mood in healthy (N = 24) and depressed (N = 30) adolescents by delivering individually tailored reward prediction errors while recording magnetoencephalography (MEG) data. Following a pre-registered analysis, we hypothesize that the expectation component of mood would be predictive of beta-gamma oscillatory power (25-40 Hz). We also hypothesize that trial variations in the source localized responses to reward feedback would be predicted by mood and by its reward prediction error component. Through our multilevel statistical analysis, we found confirmatory evidence that beta-gamma power is positively related to reward expectation during mood shifts, with localized sources in the posterior cingulate cortex. We also confirmed reward prediction error to be predictive of trial-level variations in the response of the paracentral lobule. To our knowledge, this is the first study to harness computational models of mood to relate mood fluctuations to variations in neural oscillations with MEG.

Original languageEnglish
Pages (from-to)3318-3330
Number of pages13
JournalCerebral Cortex
Issue number15
StatePublished - 1 Aug 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 The Author(s). Published by Oxford University Press. All rights reserved.


  • MEG
  • mood
  • reward prediction error
  • reward processing


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