Magnetic stimulation and the crossed-uncrossed difference (CUD) paradigm: Selective effects in the ipsilateral and contralateral hemispheres

Tzu Ching Chiang; Michal Lavidor

doi:10.1007/s00221-004-2166-9

Magnetic stimulation and the crossed-uncrossed difference (CUD) paradigm: Selective effects in the ipsilateral and contralateral hemispheres

Tzu Ching Chiang, Michal Lavidor

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

When a visual target is presented to one hemifield, manual responses made to the target using the ipsilateral hand (uncrossed responses) are faster than responses using the contralateral hand (crossed response), because there is no need for visuomotor information to be transferred between the hemispheres. This difference in response times is termed the crossed-uncrossed difference (CUD) and is a valuable means of estimating interhemispheric transfer time. We aimed to investigate the CUD by applying repetitive transcranial magnetic stimulation (rTMS) over the left and right occipital cortex during a lateralized target-detection task. Eleven neurologically healthy subjects, all right-handed, participated in the study. Relative to sham TMS we increased the CUD, by inhibiting the crossed latencies, but only when rTMS was applied to the hemisphere receiving visual information. These results replicate and extend previous findings and suggest the inhibitory rTMS effect under the crossed condition might be because the weak visual output is unable to activate the crossed pathway.

Original language	English
Pages (from-to)	404-408
Number of pages	5
Journal	Experimental Brain Research
Volume	160
Issue number	3
DOIs	https://doi.org/10.1007/s00221-004-2166-9
State	Published - Jan 2005
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgments This study was supported by the Royal Society, The Wellcome Trust (ICN), the European Commission, and a BBSRC research grant (M. Lavidor). We wish to thank Vincent Walsh for his helpful comments.

Funding

Acknowledgments This study was supported by the Royal Society, The Wellcome Trust (ICN), the European Commission, and a BBSRC research grant (M. Lavidor). We wish to thank Vincent Walsh for his helpful comments.

Funders	Funder number
ICN
Wellcome Trust
Biotechnology and Biological Sciences Research Council
Royal Society
European Commission

Keywords

Interhemispheric transfer
Occipital cortex
Poffenberger paradigm
Repetitive transcranial magnetic stimulation (rTMS)

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10.1007/s00221-004-2166-9

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title = "Magnetic stimulation and the crossed-uncrossed difference (CUD) paradigm: Selective effects in the ipsilateral and contralateral hemispheres",

abstract = "When a visual target is presented to one hemifield, manual responses made to the target using the ipsilateral hand (uncrossed responses) are faster than responses using the contralateral hand (crossed response), because there is no need for visuomotor information to be transferred between the hemispheres. This difference in response times is termed the crossed-uncrossed difference (CUD) and is a valuable means of estimating interhemispheric transfer time. We aimed to investigate the CUD by applying repetitive transcranial magnetic stimulation (rTMS) over the left and right occipital cortex during a lateralized target-detection task. Eleven neurologically healthy subjects, all right-handed, participated in the study. Relative to sham TMS we increased the CUD, by inhibiting the crossed latencies, but only when rTMS was applied to the hemisphere receiving visual information. These results replicate and extend previous findings and suggest the inhibitory rTMS effect under the crossed condition might be because the weak visual output is unable to activate the crossed pathway.",

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author = "Chiang, {Tzu Ching} and Michal Lavidor",

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Magnetic stimulation and the crossed-uncrossed difference (CUD) paradigm: Selective effects in the ipsilateral and contralateral hemispheres

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