Maghemite-containing PLGA-PEG-based polymeric nanoparticles for siRNA delivery: Toxicity and silencing evaluation

Emmanuel Lellouche; Erica Locatelli; Liron Limor Israel; Maria Naddaka; Ella Kurlander; Shulamit Michaeli; Jean Paul Lellouche; Mauro Comes Franchini

doi:10.1039/c7ra00517b

Maghemite-containing PLGA-PEG-based polymeric nanoparticles for siRNA delivery: Toxicity and silencing evaluation

Emmanuel Lellouche, Erica Locatelli, Liron Limor Israel, Maria Naddaka, Ella Kurlander, Shulamit Michaeli, Jean Paul Lellouche, Mauro Comes Franchini

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Gene therapy based on small interfering RNA (siRNA) has emerged as an exciting new therapeutic approach. In this work, incorporation of PEI into poly(d,l-lactide-co-glycolide)-poly(ethylene glycol) (PLGA-b-PEG) particles has been shown to be quite effective in the development of corresponding gene delivery systems, and encapsulation of magnetic nanoparticles as an MRI contrast agent, resulted in unique theranostic nanoparticles.

Original language	English
Pages (from-to)	26912-26920
Number of pages	9
Journal	RSC Advances
Volume	7
Issue number	43
DOIs	https://doi.org/10.1039/c7ra00517b
State	Published - 2017

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© 2017 The Royal Society of Chemistry.

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AU - Naddaka, Maria

AU - Kurlander, Ella

AU - Michaeli, Shulamit

AU - Lellouche, Jean Paul

AU - Franchini, Mauro Comes

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Maghemite-containing PLGA-PEG-based polymeric nanoparticles for siRNA delivery: Toxicity and silencing evaluation

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