Abstract
In this study we examined the expression of neurotrophins and their receptors in mouse macrophages and the effects of the neurotrophins on nitric oxide secretion. Macrophages expressed TrkB and TrkC but not BDNF, NT-3 or NT-4. LPS induced up-regulation of TrkB and TrkC and of BDNF and NT-3 expression. Treatment of macrophages with NT-3 increased the secretion of nitric oxide in LPS-treated macrophages and this increase was blocked by K252a, a Trk kinase inhibitor. In contrast, BDNF and NT-4 had no significant effects on the induction of nitric oxide. Our results suggest that NT-3 play important roles in the function of macrophages during inflammatory responses and in tissue repair. (C) 2001 Elsevier Science B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 72-77 |
| Number of pages | 6 |
| Journal | Journal of Neuroimmunology |
| Volume | 112 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 1 Jan 2001 |
Bibliographical note
Funding Information:This work was supported by the Volkswagen-Stiftung and the Wollowick Foundation. We thank Tehila Ben-Moshe and Ciska Jorna for excellent technical assistance and Avrille Goldreich for the skillful preparation of the manuscript.
Funding
This work was supported by the Volkswagen-Stiftung and the Wollowick Foundation. We thank Tehila Ben-Moshe and Ciska Jorna for excellent technical assistance and Avrille Goldreich for the skillful preparation of the manuscript.
| Funders | Funder number |
|---|---|
| Wollowick Foundation | |
| Volkswagen Foundation |
Keywords
- Macrophages
- Neurotrophin receptors
- Neurotrophins
- Nitric oxide