Ménage à trois: regulation of host immunity by enteric neuro-immune-microbiota cross talks

Nissan Yissachar

doi:10.1016/j.conb.2019.10.006

Ménage à trois: regulation of host immunity by enteric neuro-immune-microbiota cross talks

Nissan Yissachar

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Over the past decade, our understanding of intestinal immunology has been transformed by the realization that the gut microbiota shapes immune development, function and disease susceptibility. Strikingly, the enteric nervous system is now emerging as a cellular hub that sense microbiota-derived signals and rapidly orchestrate immunological outcomes. Here, I discuss recent advances in our understanding of intestinal neuroimmune communications, their modulation by the gut microbiota, and the consequent impact on host immunity, in health and disease.

Original language	English
Pages (from-to)	26-33
Number of pages	8
Journal	Current Opinion in Neurobiology
Volume	62
Early online date	4 Dec 2019
DOIs	https://doi.org/10.1016/j.conb.2019.10.006
State	Published - Jun 2020

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

Funding

I thank members of my lab for fruitful discussions and comments on the manuscript. This work was supported by the Israel Science Foundation (grant No. 3114831 ), the Israel Science Foundation — Broad Institute Joint Program (grant No. 8165162 ), the Israel Cancer Association , Crown family philanthropies, and the Heilbut family (Toronto, Canada). I thank members of my lab for fruitful discussions and comments on the manuscript. This work was supported by the Israel Science Foundation (grant No. 3114831), the Israel Science Foundation ? Broad Institute Joint Program (grant No. 8165162), the Israel Cancer Association, Crown family philanthropies, and the Heilbut family (Toronto, Canada).

Funders	Funder number
Heilbut family
Israel Science Foundation — Broad Institute	8165162
Crown Family Philanthropies
Israel Cancer Association
Israel Science Foundation	3114831

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10.1016/j.conb.2019.10.006

Cite this

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Ménage à trois: regulation of host immunity by enteric neuro-immune-microbiota cross talks

Abstract

Bibliographical note

Funding

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