Lysozyme: A Double-Edged Sword in the Intestine

Mor Zigdon; Shai Bel

doi:10.1016/j.it.2020.10.010

Lysozyme: A Double-Edged Sword in the Intestine

Mor Zigdon, Shai Bel

Bar-Ilan University - Azrieli Faculty of Medicine

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

Lysozyme-secreting Paneth cells are abnormally present in the distal colons of patients with inflammatory bowel disease (IBD), along with high amounts of lysozyme in feces. In a recent article in Immunity, Yu et al. show that lysozyme-mediated processing of luminal bacteria in the colon triggers a proinflammatory response and predisposes mice to experimental IBD.

Original language	English
Pages (from-to)	1054-1056
Number of pages	3
Journal	Trends in Immunology
Volume	41
Issue number	12
DOIs	https://doi.org/10.1016/j.it.2020.10.010
State	Published - Dec 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd

Keywords

colitis
immune response
inflammatory bowel diseases
lysozyme
microbiota

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10.1016/j.it.2020.10.010

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abstract = "Lysozyme-secreting Paneth cells are abnormally present in the distal colons of patients with inflammatory bowel disease (IBD), along with high amounts of lysozyme in feces. In a recent article in Immunity, Yu et al. show that lysozyme-mediated processing of luminal bacteria in the colon triggers a proinflammatory response and predisposes mice to experimental IBD.",

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KW - microbiota

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Lysozyme: A Double-Edged Sword in the Intestine

Abstract

Bibliographical note

Keywords

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