Lysozyme: A Double-Edged Sword in the Intestine

Mor Zigdon, Shai Bel

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations


Lysozyme-secreting Paneth cells are abnormally present in the distal colons of patients with inflammatory bowel disease (IBD), along with high amounts of lysozyme in feces. In a recent article in Immunity, Yu et al. show that lysozyme-mediated processing of luminal bacteria in the colon triggers a proinflammatory response and predisposes mice to experimental IBD.

Original languageEnglish
Pages (from-to)1054-1056
Number of pages3
JournalTrends in Immunology
Issue number12
StatePublished - Dec 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd


  • colitis
  • immune response
  • inflammatory bowel diseases
  • lysozyme
  • microbiota


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