Lymphocyte subset reference ranges in healthy Israeli adults

Yael Shahal-Zimra, Zohar Rotem, Judith Chezar, Tzippy Shochat, Liron Ross, Itai Pickholtz, Esther Rabizadeh

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Reference ranges for adult peripheral blood lymphocyte subsets have been established in a few countries. To the best of our knowledge no broad lymphocyte subset analysis of the Israeli population has been reported. Objectives: To establish reference ranges for healthy adults in Israel and to describe age- and gender-specific differences, if present. Methods: Lymphocyte subsets CD3, CD3/CD4, CD3/CD8, CD3-/ CD16+/CD56+, CD3/TCRαβ, CD3/TCRγδ, and CD19 were examined by flow cytometry in 326 subjects. Samples were subdivided according to age and gender. Results: Women of all ages had a significantly higher percentage and absolute counts of CD3/CD4 cells than their male counterparts. Higher CD3/CD4 cells were observed also in the older population (> 50 years). CD3/CD8 and CD3-/CD16+/CD56+ were higher in males. Older males had a lower total lymphocyte percentage and CD19 cells compared to younger men. No significant gender-related differences were observed in percent and number of CD19, CD3/TCRαβ or CD3/TCRγδ at all ages. Conclusions: These reference values could be useful in further studies for assessing changes that occur in different populations in human pathology.

Original languageEnglish
Pages (from-to)673-677
Number of pages5
JournalIsrael Medical Association Journal
Issue number12
StatePublished - Dec 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016, Israel Medical Association. All rights reserved.


  • CD3 CD3-CD16/CD56+
  • CD4
  • CD8
  • Lymphocytes


Dive into the research topics of 'Lymphocyte subset reference ranges in healthy Israeli adults'. Together they form a unique fingerprint.

Cite this