Lymphocyte Subset Reference Ranges in Healthy Israeli Adults

Yael Shahal-Zimra, Zohar Rotem, Judith Chezar, Tzippy Shochat, Liron Ross, Itai Pickholtz, Esther Rabizadeh

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

BACKGROUND: Reference ranges for adult peripheral blood lymphocyte subsets have been established in a few countries. To the best of our knowledge no broad lymphocyte subset analysis of the Israeli population has been reported.  Objectives: To establish reference ranges for healthy adults in Israel and to describe age- and gender-specific differences, if present.

OBJECTIVES: To establish reference ranges for healthy adults in Israel and to describe age- and gender-specific differences, if present.

METHODS: Lymphocyte subsets CD3, CD3/CD4, CD3/CD8, CD3-/CD16+/CD56+, CD3/TCRαβ, CD3/TCRγδ, and CD19 were examined by flow cytometry in 326 subjects. Samples were subdivided according to age and gender.

RESULTS: Women of all ages had a significantly higher percentage and absolute counts of CD3/CD4 cells than their male counterparts. Higher CD3/CD4 cells were observed also in the older population (> 50 years). CD3/CD8 and CD3-/CD16+/CD56+ were higher in males. Older males had a lower total lymphocyte percentage and CD19 cells compared to younger men. No significant gender-related differences were observed in percent and number of CD19, CD3/TCRαβ or CD3/TCRγδ at all ages.

CONCLUSIONS: These reference values could be useful in further studies for assessing changes that occur in different populations in human pathology.

Original languageEnglish
Pages (from-to)739-743
Number of pages5
JournalIsrael Medical Association Journal
Volume18
Issue number12
StatePublished - 1 Dec 2016
Externally publishedYes

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