Abstract
BACKGROUND: Reference ranges for adult peripheral blood lymphocyte subsets have been established in a few countries. To the best of our knowledge no broad lymphocyte subset analysis of the Israeli population has been reported. Objectives: To establish reference ranges for healthy adults in Israel and to describe age- and gender-specific differences, if present.
OBJECTIVES: To establish reference ranges for healthy adults in Israel and to describe age- and gender-specific differences, if present.
METHODS: Lymphocyte subsets CD3, CD3/CD4, CD3/CD8, CD3-/CD16+/CD56+, CD3/TCRαβ, CD3/TCRγδ, and CD19 were examined by flow cytometry in 326 subjects. Samples were subdivided according to age and gender.
RESULTS: Women of all ages had a significantly higher percentage and absolute counts of CD3/CD4 cells than their male counterparts. Higher CD3/CD4 cells were observed also in the older population (> 50 years). CD3/CD8 and CD3-/CD16+/CD56+ were higher in males. Older males had a lower total lymphocyte percentage and CD19 cells compared to younger men. No significant gender-related differences were observed in percent and number of CD19, CD3/TCRαβ or CD3/TCRγδ at all ages.
CONCLUSIONS: These reference values could be useful in further studies for assessing changes that occur in different populations in human pathology.
Original language | English |
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Pages (from-to) | 739-743 |
Number of pages | 5 |
Journal | Israel Medical Association Journal |
Volume | 18 |
Issue number | 12 |
State | Published - 1 Dec 2016 |
Externally published | Yes |