Low catalytic activity of the Cu(II)-binding motif (Xxx-Zzz-His; ATCUN) in reactive oxygen species production and inhibition by the Cu(i)-chelator BCS

Alice Santoro, Gulshan Walke, Bertrand Vileno, Prasad P. Kulkarni, Laurent Raibaut, Peter Faller

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21 Scopus citations

Abstract

The catalytic redox activity of Cu(ii) bound to the motif NH2-Xxx-Zzz-His (ATCUN) with ascorbate and H2O2/O2 is very low and can be stopped via Cu(i)-chelation. This impacts its application as an artificial Cu-enzyme to degrade biomolecules via production of reactive oxygen species in a Cu(i)-chelator rich environment like the cytosol.

Original languageEnglish
Pages (from-to)11945-11948
Number of pages4
JournalChemical Communications
Volume54
Issue number84
DOIs
StatePublished - 18 Oct 2018

Bibliographical note

Publisher Copyright:
© 2018 The Royal Society of Chemistry.

Funding

A. S. and G. W were supported by the IDEX PhD program (University of Strasbourg) and an EMBO short-term fellowship (ASTF 505-2016), respectively. The Frontier Research in Chemistry Foundation of Strasbourg (P. F.), the University of Strasbourg Institute for Advanced Study (USIAS) (P. F.), IDEX attractivity program of the University of Strasbourg (L. R.) and the Reseau NAtional de Rpe interDisciplinaire (RENARD, Fédération IR-RPE CNRS #3443) are acknowledged. P. F. would like to thank Dr C. Hureau (LCC, Toulouse) for helpful discussions. P. K. would like to acknowledge funds from the Department of Science and Technology, India (EMR/2014/001235). We would like to thank Dr Romain Ruppert (UMR7177 - Institut de Chimie, Strasbourg) for the gift of the Phen and DmBipy compound.

FundersFunder number
European Molecular Biology OrganizationASTF 505-2016

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