Loss of systemic endothelial function post-PCI

Bo Han, Diab Ghanim, Aviva Peleg, Gideon Uretzky, Yonathan Hasin

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

To investigate loss of systemic endothelial function post-PCI and evaluate the putative therapeutic effect of BNP. Loss of endothelial function (LEF) post-PCI may contribute to both acute and long-term complications. A protective effect of BNP on endothelium was suggested previously. Flow-mediated vasodilation (FMD) of the brachial artery, as well as plasma levels of endothelin, BNP, Pro BNP and corin were measured before and following routine PCI. 49 patients with normal baseline endothelial function were recruited. 30 patients developed LEF and were randomized to i.v. nesiritide (the commercially available recombinant form of human BNP) or saline infusion for 3 h. Patients who developed LEF post-PCI had reduced baseline plasma corin levels and their BNP/ProBNP ratio was reduced after the procedure. Nesiritide infusion significantly improved FMD both immediately (Nesiritide versus saline: 2.87±0.78% versus 0.51±0.25%, P=0.007) and 24 h after the treatment (2.52±0.69% versus 0.72±0.32%, P=0.025). The elevated plasma ET-1 was reduced by Nesiritide (0.38±0.11 fmol/ml 24 h post-PCI versus 0.16±0.02 fmol/ml 24 h post BNP, P=0.047), but remained unchanged in saline group (0.39±0.21 fmol/ml versus 0.42±0.23 fmol/ml, P=0.749). Systemic LEF post-PCI is a frequent event. It may be related to impaired cleavage of ProBNP to BNP. Short-term i.v. nesiritide improves systemic LEF post-PCI.

Original languageEnglish
Pages (from-to)79-87
Number of pages9
JournalAcute Cardiac Care
Volume10
Issue number2
DOIs
StatePublished - 2008
Externally publishedYes

Bibliographical note

Funding Information:
This research was partially supported by the Tech-nion’s Eliyahoo Pen fund for medical research of the Technion, Haifa.

Funding

This research was partially supported by the Tech-nion’s Eliyahoo Pen fund for medical research of the Technion, Haifa.

FundersFunder number
Tech-nion’s Eliyahoo Pen fund
Technion, Haifa

    Keywords

    • Angioplasty
    • Contrast media
    • Endothelin
    • Endothelium
    • Natriuretic peptides

    Fingerprint

    Dive into the research topics of 'Loss of systemic endothelial function post-PCI'. Together they form a unique fingerprint.

    Cite this