Abstract
The gene for insulin-like growth factor two, IGF2 is maternally imprinted. Fifteen heterozygous samples were analyzed for the IGF2 imprinting status and promoter usage. IGF2 LOI was detected in four non-tumorous tissues and in six laryngeal squamous cell carcinoma (LSCC) tumors. There was no clear pattern of specific promoter activity in LSCC tumors and the adjacent normal tissues. P1 promoter usage was active in eight LSCCs, among them four with LOI. As it was activated in four tumors with maintenance of imprinting (MOI) and four non-tumors, we concluded that P1 promoter is not exclusively connected with IGF2 LOI in LSCC.
| Original language | English |
|---|---|
| Pages (from-to) | 224-229 |
| Number of pages | 6 |
| Journal | Cancer Letters |
| Volume | 238 |
| Issue number | 2 |
| DOIs | |
| State | Published - 18 Jul 2006 |
| Externally published | Yes |
Bibliographical note
Funding Information:We thank Iva Karlovic for technical assistance during this project and Mr. Aaron Etra for helping us on preparing the manuscript. This work was supported by grant 0098095 Ministry of Science and Technology of the Republic of Croatia.
Funding
We thank Iva Karlovic for technical assistance during this project and Mr. Aaron Etra for helping us on preparing the manuscript. This work was supported by grant 0098095 Ministry of Science and Technology of the Republic of Croatia.
| Funders | Funder number |
|---|---|
| Ministry of Science and Technology, Croatia |
Keywords
- IGF2
- Imprinting
- Laryngeal squamous cell carcinoma
- Promoter usage
