TY - JOUR
T1 - Longitudinal analysis of growth over the first 3 years of life in Turner's syndrome
AU - Even, Lea
AU - Cohen, Ayala
AU - Marbach, Naama
AU - Brand, Manuela
AU - Kauli, Rivka
AU - Sippell, Wolfgang
AU - Hochberg, Ze'ev
PY - 2000/10
Y1 - 2000/10
N2 - Objective: To evaluate longitudinal growth in Turner's syndrome (TS) over the first 3 years of life. Methods: Growth of 47 patients with TS was compared with that of 40 age-matched control girls by using an analysis according to the Infancy-Childhood-Puberty and bi-exponential models. Results: A mean of 1.2 SDs were lost before birth and a total of 3.0 SDs were lost by age 3 years. According to the Infancy-Childhood-Puberty model, intrauterine growth retardation contributed -1.24 SDs, a 5-month delay in childhood growth spurt contributed -0.96 SDs, and slow childhood growth contributed an additional -0.8 SDs by age 3 years. The bi-exponential analysis disclosed a quasi-linear first exponent and a confining second exponent, which merged at age 18 months in control subjects and 24 months in patients with TS. The first exponent confers an average annual growth rate of 8.4 cm/y in control subjects and 6.7 cm/y in patients with TS. Conclusions: Intrauterine growth retardation and the initial 3 years of life contribute most of the deficit in the final height of patients with TS. These data provide a reference of standards for longitudinal growth in patients with TS at age 3 months to 3 years.
AB - Objective: To evaluate longitudinal growth in Turner's syndrome (TS) over the first 3 years of life. Methods: Growth of 47 patients with TS was compared with that of 40 age-matched control girls by using an analysis according to the Infancy-Childhood-Puberty and bi-exponential models. Results: A mean of 1.2 SDs were lost before birth and a total of 3.0 SDs were lost by age 3 years. According to the Infancy-Childhood-Puberty model, intrauterine growth retardation contributed -1.24 SDs, a 5-month delay in childhood growth spurt contributed -0.96 SDs, and slow childhood growth contributed an additional -0.8 SDs by age 3 years. The bi-exponential analysis disclosed a quasi-linear first exponent and a confining second exponent, which merged at age 18 months in control subjects and 24 months in patients with TS. The first exponent confers an average annual growth rate of 8.4 cm/y in control subjects and 6.7 cm/y in patients with TS. Conclusions: Intrauterine growth retardation and the initial 3 years of life contribute most of the deficit in the final height of patients with TS. These data provide a reference of standards for longitudinal growth in patients with TS at age 3 months to 3 years.
UR - http://www.scopus.com/inward/record.url?scp=0033765169&partnerID=8YFLogxK
U2 - 10.1067/mpd.2000.109110
DO - 10.1067/mpd.2000.109110
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C2 - 11035821
AN - SCOPUS:0033765169
SN - 0022-3476
VL - 137
SP - 460
EP - 464
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 4
ER -