Long-term trajectories and current BMI are associated with poorer cognitive functioning in middle-aged adults at high Alzheimer's disease risk

Rebecca K. West; Ramit Ravona-Springer; Inbal Sharvit-Ginon; Ithamar Ganmore; Sigalit Manzali; Amir Tirosh; Sapir Golan; Ethel Boccara; Anthony Heymann; Michal Schnaider Beeri

doi:10.1002/dad2.12247

Long-term trajectories and current BMI are associated with poorer cognitive functioning in middle-aged adults at high Alzheimer's disease risk

Rebecca K. West, Ramit Ravona-Springer, Inbal Sharvit-Ginon, Ithamar Ganmore, Sigalit Manzali, Amir Tirosh, Sapir Golan, Ethel Boccara, Anthony Heymann, Michal Schnaider Beeri

Department of Psychology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Introduction: We examined relationships of body mass index (BMI) with cognition in middle-aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods: Participants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history. Analyses of covariance examined associations of long-term trajectories of BMI with cognition. Results: Higher BMI was associated with worse language (P =.045). Interactions of BMI with parental history were significant for episodic memory (P =.023), language (p =.027), working memory (P =.006), global cognition (P =.008); associations were stronger among participants with maternal history. Interactions of BMI trajectories with parental history were significant for episodic memory (P =.017), language (P =.013), working memory (P =.001), global cognition (P =.005), with stronger associations for maternal history. Discussion: Higher BMI and overweight/obese trajectories were associated with poorer cognition in adults with maternal history of AD, but not those with paternal history.

Original language	English
Article number	e12247
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	13
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12247
State	Published - 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association

Funding

Rebecca K. West reports that in addition to her work at the Icahn School of Medicine at Mount Sinai, she is paid as an adjunct assistant professor and a researcher at the City University of New York. Ramit Ravona‐Springer received funding from Tel Aviv University internal grants—the Brecher foundation and the Ofer Mordechai Foundation, the ARC (Accelerate, Redesign, Collaborate) Innovation Center at the Sheba Medical Center, the ADDF (Alzheimer's Drug Discovery Foundation). Inbal Sharvit Ginon received travel support for attending AAIC 2018 and AAIC 2019, as PhD student at the Joseph Sagol Neuroscience Center at Sheba Medical Center, Israel. Ithamar Ganmore reports no disclosures. Sigalit Manzali reports no disclosures. Sapir Golan reports no disclosures. Ethel Boccara reports no disclosures.Anthony Heymann received consulting fees from pharmaceutical companies Boehringer Ingelheim Israel, Rafa Israel, and Kamada, and payment for expert testimony in medical negligence cases in Israel courts. Michal Schnaider Beeri reports no disclosures. Study funded by NIH (AG02219/AG/NIA NIH HHS, P01‐AG02219/AG/NIA NIH HHS, R01 AG034087/AG/NIA NIH HHS, AG051545/AG/NIA NIH HHS, AG053446/AG/NIA NIH HHS, AG061093/AG/NIA NIH HHS), provided to the institutions listed in this manuscript. We thank the LeRoy Schecter Foundation and Dr. Marina Nissim for their kind financial gifts that supported this study. Study funded by NIH (AG02219/AG/NIA NIH HHS, P01-AG02219/AG/NIA NIH HHS, R01 AG034087/AG/NIA NIH HHS, AG051545/AG/NIA NIH HHS, AG053446/AG/NIA NIH HHS, AG061093/AG/NIA NIH HHS), provided to the institutions listed in this manuscript.

Funders	Funder number
Brecher foundation
LeRoy Schecter Foundation
NIH HHS	P01‐AG02219/AG/NIA
Ofer Mordechai Foundation
Sheba Medical Center
National Institutes of Health
Alzheimer's Drug Discovery Foundation
Automotive Research Center
Tel Aviv University

Keywords

Alzheimer's disease
adiposity
cognition
cognitive decline
obesity
parental history of Alzheimer's disease
risk factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/dad2.12247

Cite this

West, R. K., Ravona-Springer, R., Sharvit-Ginon, I., Ganmore, I., Manzali, S., Tirosh, A., Golan, S., Boccara, E., Heymann, A., & Beeri, M. S. (2021). Long-term trajectories and current BMI are associated with poorer cognitive functioning in middle-aged adults at high Alzheimer's disease risk. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 13(1), Article e12247. https://doi.org/10.1002/dad2.12247

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title = "Long-term trajectories and current BMI are associated with poorer cognitive functioning in middle-aged adults at high Alzheimer's disease risk",

abstract = "Introduction: We examined relationships of body mass index (BMI) with cognition in middle-aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods: Participants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history. Analyses of covariance examined associations of long-term trajectories of BMI with cognition. Results: Higher BMI was associated with worse language (P =.045). Interactions of BMI with parental history were significant for episodic memory (P =.023), language (p =.027), working memory (P =.006), global cognition (P =.008); associations were stronger among participants with maternal history. Interactions of BMI trajectories with parental history were significant for episodic memory (P =.017), language (P =.013), working memory (P =.001), global cognition (P =.005), with stronger associations for maternal history. Discussion: Higher BMI and overweight/obese trajectories were associated with poorer cognition in adults with maternal history of AD, but not those with paternal history.",

keywords = "Alzheimer's disease, adiposity, cognition, cognitive decline, obesity, parental history of Alzheimer's disease, risk factors",

author = "West, {Rebecca K.} and Ramit Ravona-Springer and Inbal Sharvit-Ginon and Ithamar Ganmore and Sigalit Manzali and Amir Tirosh and Sapir Golan and Ethel Boccara and Anthony Heymann and Beeri, {Michal Schnaider}",

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year = "2021",

doi = "10.1002/dad2.12247",

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West, RK, Ravona-Springer, R, Sharvit-Ginon, I, Ganmore, I, Manzali, S, Tirosh, A, Golan, S, Boccara, E, Heymann, A & Beeri, MS 2021, 'Long-term trajectories and current BMI are associated with poorer cognitive functioning in middle-aged adults at high Alzheimer's disease risk', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 13, no. 1, e12247. https://doi.org/10.1002/dad2.12247

Long-term trajectories and current BMI are associated with poorer cognitive functioning in middle-aged adults at high Alzheimer's disease risk. / West, Rebecca K.; Ravona-Springer, Ramit; Sharvit-Ginon, Inbal et al.
In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 13, No. 1, e12247, 2021.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Long-term trajectories and current BMI are associated with poorer cognitive functioning in middle-aged adults at high Alzheimer's disease risk

AU - West, Rebecca K.

AU - Ravona-Springer, Ramit

AU - Sharvit-Ginon, Inbal

AU - Ganmore, Ithamar

AU - Manzali, Sigalit

AU - Tirosh, Amir

AU - Golan, Sapir

AU - Boccara, Ethel

AU - Heymann, Anthony

AU - Beeri, Michal Schnaider

PY - 2021

Y1 - 2021

N2 - Introduction: We examined relationships of body mass index (BMI) with cognition in middle-aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods: Participants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history. Analyses of covariance examined associations of long-term trajectories of BMI with cognition. Results: Higher BMI was associated with worse language (P =.045). Interactions of BMI with parental history were significant for episodic memory (P =.023), language (p =.027), working memory (P =.006), global cognition (P =.008); associations were stronger among participants with maternal history. Interactions of BMI trajectories with parental history were significant for episodic memory (P =.017), language (P =.013), working memory (P =.001), global cognition (P =.005), with stronger associations for maternal history. Discussion: Higher BMI and overweight/obese trajectories were associated with poorer cognition in adults with maternal history of AD, but not those with paternal history.

AB - Introduction: We examined relationships of body mass index (BMI) with cognition in middle-aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods: Participants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history. Analyses of covariance examined associations of long-term trajectories of BMI with cognition. Results: Higher BMI was associated with worse language (P =.045). Interactions of BMI with parental history were significant for episodic memory (P =.023), language (p =.027), working memory (P =.006), global cognition (P =.008); associations were stronger among participants with maternal history. Interactions of BMI trajectories with parental history were significant for episodic memory (P =.017), language (P =.013), working memory (P =.001), global cognition (P =.005), with stronger associations for maternal history. Discussion: Higher BMI and overweight/obese trajectories were associated with poorer cognition in adults with maternal history of AD, but not those with paternal history.

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KW - adiposity

KW - cognition

KW - cognitive decline

KW - obesity

KW - parental history of Alzheimer's disease

KW - risk factors

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C2 - 35005193

AN - SCOPUS:85124409710

SN - 2352-8729

VL - 13

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

IS - 1

M1 - e12247

ER -

Long-term trajectories and current BMI are associated with poorer cognitive functioning in middle-aged adults at high Alzheimer's disease risk

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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