TY - JOUR
T1 - Long-term prognosis in young patients with acute coronary syndrome treated with percutaneous coronary intervention
AU - Yagel, Oren
AU - Shadafny, Naseem
AU - Eliaz, Ran
AU - Dagan, Gil
AU - Leibowitz, David
AU - Tahiroglu, Ilgar
AU - Planer, David
AU - Amir, Offer
AU - Greener, Gabby Elbaz
AU - Alcalai, Ronny
N1 - Publisher Copyright:
© 2021 Yagel et al.
PY - 2021
Y1 - 2021
N2 - Background: Acute coronary syndrome (ACS) at a young age is uncommon. Limited data regarding the long-term follow-up and prognosis in this population are available. Our objectives were to evaluate the long-term clinical outcomes of patients presenting with ACS at a young age and to assess factors that predict long-term prognosis. Methods: A retrospective analysis of consecutive young patients (male below 40 and female below 50 years old) that were admitted with ACS and underwent percutaneous coronary intervention (PCI) between the years 1997 and 2009. Demographics, clinical characteristics, and clinical outcomes including major cardiovascular (CV) events and mortality were analyzed. Multivariable cox proportional hazard model was performed to identify predictors of long-term prognosis. Results: One-hundred sixty-five patients were included with a mean follow-up of 9.1±4.6 years. Most patients were men (88%), and mean age (years) was 36.8±4.2. During follow-up, 15 (9.1%) died, 98 (59.4%) patients had at least one major CV event, 22 (13.3%) patients had more than two CV events, and the mean number of recurrent CV events was 1.4±1.48 events per patient. In multivariate analysis, the strongest predictors of major CV events and/or mortality were coronary intervention without stent insertion (HR1.77; 95% CI 1.09–2.9), LAD artery involvement (HR 1.59; 95% CI 1.04–2.44) and hypertension (HR 1.6; 95% CI 1.0–2.6). Conclusion: Patients with ACS in young age are at high risk for major CV and/or mortality in long-term follow-up with a high rate of recurrent CV events. Close follow-up and risk factor management for secondary prevention have a major role, particularly in this population.
AB - Background: Acute coronary syndrome (ACS) at a young age is uncommon. Limited data regarding the long-term follow-up and prognosis in this population are available. Our objectives were to evaluate the long-term clinical outcomes of patients presenting with ACS at a young age and to assess factors that predict long-term prognosis. Methods: A retrospective analysis of consecutive young patients (male below 40 and female below 50 years old) that were admitted with ACS and underwent percutaneous coronary intervention (PCI) between the years 1997 and 2009. Demographics, clinical characteristics, and clinical outcomes including major cardiovascular (CV) events and mortality were analyzed. Multivariable cox proportional hazard model was performed to identify predictors of long-term prognosis. Results: One-hundred sixty-five patients were included with a mean follow-up of 9.1±4.6 years. Most patients were men (88%), and mean age (years) was 36.8±4.2. During follow-up, 15 (9.1%) died, 98 (59.4%) patients had at least one major CV event, 22 (13.3%) patients had more than two CV events, and the mean number of recurrent CV events was 1.4±1.48 events per patient. In multivariate analysis, the strongest predictors of major CV events and/or mortality were coronary intervention without stent insertion (HR1.77; 95% CI 1.09–2.9), LAD artery involvement (HR 1.59; 95% CI 1.04–2.44) and hypertension (HR 1.6; 95% CI 1.0–2.6). Conclusion: Patients with ACS in young age are at high risk for major CV and/or mortality in long-term follow-up with a high rate of recurrent CV events. Close follow-up and risk factor management for secondary prevention have a major role, particularly in this population.
KW - ACS
KW - Acute coronary syndrome
KW - NSTEMI
KW - Outcomes
KW - STEMI
KW - Young population
UR - http://www.scopus.com/inward/record.url?scp=85105032118&partnerID=8YFLogxK
U2 - 10.2147/VHRM.S298436
DO - 10.2147/VHRM.S298436
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C2 - 33907409
AN - SCOPUS:85105032118
SN - 1176-6344
VL - 17
SP - 153
EP - 159
JO - Vascular Health and Risk Management
JF - Vascular Health and Risk Management
ER -