Long-range synchrony and emergence of neural reentry

Hanna Keren, Shimon Marom

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Neural synchronization across long distances is a functionally important phenomenon in health and disease. In order to access the basis of different modes of long-range synchrony, we monitor spiking activities over centimetre scale in cortical networks and show that the mode of synchrony depends upon a length scale, Λ, which is the minimal path that activity should propagate through to find its point of origin ready for reactivation. When Î" is larger than the physical dimension of the network, distant neuronal populations operate synchronously, giving rise to irregularly occurring network-wide events that last hundreds of milliseconds to several seconds. In contrast, when Λ approaches the dimension of the network, a continuous self-sustained reentry propagation emerges, a regular seizure-like mode that is marked by precise spatiotemporal patterns ('synfire chains') and may last many minutes. Termination of a reentry phase is preceded by a decrease of propagation speed to a halt. Stimulation decreases both propagation speed and λ values, which modifies the synchrony mode respectively. The results contribute to the understanding of the origin and termination of different modes of neural synchrony as well as their long-range spatial patterns, while hopefully catering to manipulation of the phenomena in pathological conditions.

Original languageEnglish
Article number36837
JournalScientific Reports
StatePublished - 22 Nov 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 The Author(s).


FundersFunder number
Seventh Framework Programme269459


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