Long range correlations in healthy dynamics and their breakdown with disease: A new paradigm for physiological monitoring

Ary L. Goldberger; Chung Kang Peng; Joseph Mietus; Jeffrey M. Hausdorff; Shlomo Havlin; H. Eugene Stanley

doi:10.1109/iembs.1992.5761330

Long range correlations in healthy dynamics and their breakdown with disease: A new paradigm for physiological monitoring

Ary L. Goldberger, Chung Kang Peng, Joseph Mietus, Jeffrey M. Hausdorff, Shlomo Havlin, H. Eugene Stanley

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

We propose a new framework for conceptualizing and quantitating the dynamics of health and disease, using neuroautonomic regulation of the heartbeat as a model system. This theory is based on two postulates: 1) Complex physiological systems operate far from equilibrium and demonstrate long-range correlations indicative of a fractal (scale-invariant) mechanism; 2) Pathologic dynamics are marked by a breakdown in this long-range correlation behavior.

Original language	English
Title of host publication	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
Editors	Jean Pierre Morucci, Jean Louis Coatrieux, Swamy Laxminarayan, Robert Plonsey
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	969-970
Number of pages	2
ISBN (Electronic)	0780307852
DOIs	https://doi.org/10.1109/iembs.1992.5761330
State	Published - 1992
Externally published	Yes
Event	14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992 - Paris, France Duration: 29 Oct 1992 → 1 Nov 1992

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	3
ISSN (Print)	1557-170X

Conference

Conference	14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
Country/Territory	France
City	Paris
Period	29/10/92 → 1/11/92

Bibliographical note

Publisher Copyright:
© 1992 IEEE.

Access to Document

10.1109/iembs.1992.5761330

Cite this

Goldberger, A. L., Peng, C. K., Mietus, J., Hausdorff, J. M., Havlin, S., & Stanley, H. E. (1992). Long range correlations in healthy dynamics and their breakdown with disease: A new paradigm for physiological monitoring. In J. P. Morucci, J. L. Coatrieux, S. Laxminarayan, & R. Plonsey (Eds.), Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992 (pp. 969-970). Article 5761330 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 3). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/iembs.1992.5761330

Goldberger, Ary L. ; Peng, Chung Kang ; Mietus, Joseph et al. / Long range correlations in healthy dynamics and their breakdown with disease : A new paradigm for physiological monitoring. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992. editor / Jean Pierre Morucci ; Jean Louis Coatrieux ; Swamy Laxminarayan ; Robert Plonsey. Institute of Electrical and Electronics Engineers Inc., 1992. pp. 969-970 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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author = "Goldberger, {Ary L.} and Peng, {Chung Kang} and Joseph Mietus and Hausdorff, {Jeffrey M.} and Shlomo Havlin and Stanley, {H. Eugene}",

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doi = "10.1109/iembs.1992.5761330",

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series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

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Goldberger, AL, Peng, CK, Mietus, J, Hausdorff, JM, Havlin, S & Stanley, HE 1992, Long range correlations in healthy dynamics and their breakdown with disease: A new paradigm for physiological monitoring. in JP Morucci, JL Coatrieux, S Laxminarayan & R Plonsey (eds), Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992., 5761330, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 3, Institute of Electrical and Electronics Engineers Inc., pp. 969-970, 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992, Paris, France, 29/10/92. https://doi.org/10.1109/iembs.1992.5761330

Long range correlations in healthy dynamics and their breakdown with disease: A new paradigm for physiological monitoring. / Goldberger, Ary L.; Peng, Chung Kang; Mietus, Joseph et al.
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992. ed. / Jean Pierre Morucci; Jean Louis Coatrieux; Swamy Laxminarayan; Robert Plonsey. Institute of Electrical and Electronics Engineers Inc., 1992. p. 969-970 5761330 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 3).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Goldberger AL, Peng CK, Mietus J, Hausdorff JM, Havlin S, Stanley HE. Long range correlations in healthy dynamics and their breakdown with disease: A new paradigm for physiological monitoring. In Morucci JP, Coatrieux JL, Laxminarayan S, Plonsey R, editors, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992. Institute of Electrical and Electronics Engineers Inc. 1992. p. 969-970. 5761330. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/iembs.1992.5761330

Long range correlations in healthy dynamics and their breakdown with disease: A new paradigm for physiological monitoring

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