Abstract
Prolonged postoperative analgesia cannot be achieved using single injections of local anesthetic solutions. The study objective was to evaluate the efficacy and toxicity of a new formulation of bupivacaine loaded in an injectable fatty acid based biodegradable polymer poly(sebacic-co-ricinoleic acid) for producing motor and sensory block when injected near the sciatic nerve. Bupivacaine was dissolved in poly(fatty ester-anhydride) paste and tested for drug release in vitro and in vivo after injection in mice. The efficacy and toxicity of the polymer-drug combination was determined by injecting the polymer formulation near the sciatic nerve of mice and measure the sensory and motor nerve blockade for 48 h, while monitoring the animal general health and the injection site. Seventy percent of the incorporated drug was released during 1 week in vitro. Single injection of 10% bupivacaine in the polymer caused motor and sensory block that lasted 30 h. Microscopic examination of the injection sites revealed only mild infiltration in three of eight examined tissues with no pathological findings for internal organs were found. In conclusion the polymer poly(sebacic-co-ricinoleic acid) is a safe carrier for prolonged activity of bupivacaine.
Original language | English |
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Pages (from-to) | 97-103 |
Number of pages | 7 |
Journal | Journal of Controlled Release |
Volume | 117 |
Issue number | 1 |
DOIs | |
State | Published - 22 Jan 2007 |
Externally published | Yes |
Bibliographical note
Funding Information:Funding: This study was supported (in part) by grant no. 5868 from the Chief Scientist Office of the Ministry of Health, Israel and a grant from the Joint Research Fund of the Hebrew University and Hadassah Medical Organization, Jerusalem, Israel.
Funding
Funding: This study was supported (in part) by grant no. 5868 from the Chief Scientist Office of the Ministry of Health, Israel and a grant from the Joint Research Fund of the Hebrew University and Hadassah Medical Organization, Jerusalem, Israel.
Funders | Funder number |
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Joint Research Fund of the Hebrew University | |
Hadassah Medical Organization | |
Ministry of Health, State of Israel |
Keywords
- Analgesia
- Animal
- Local anesthetic
- Long-acting
- Polymer-bupivacaine