Loading magnetic nanoparticles into sperm cells does not affect their functionality

Shirly Ben David Makhluf, Riam Qasem, Sara Rubinstein, Aharon Gedanken, Haim Breitbart

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

The spontaneous loading of magnetite nanoparticles into sperm cell was carried out by mixing an aqueous colloidal solution of Fe3O 4-PVA with sperm cells (108 cells/ml) for 2 h at 37 °C suspended in glucose-free modified Tyrode solution. The penetration of the magnetite nanoparticles into the sperm cells was monitored by conventional analytical chemistry. We have demonstrated that the motility and the ability to undergo the acrosome reaction (i.e., the ability to fertilize the egg) were not affected by the presence of the magnetite nanoparticles.

Original languageEnglish
Pages (from-to)9480-9482
Number of pages3
JournalLangmuir
Volume22
Issue number23
DOIs
StatePublished - 7 Nov 2006

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