Interleukin-3 immunoassay in systemic lupus erythematosus patients: Preliminary data

P. Fishman, M. Kamashta, M. Ehrenfeld, J. Vianna, G. R.V. Hughes, D. Sredni, R. Zigelman, G. Sabo, Y. Shoenfeld

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) may be associated with thrombocytopenia on one hand and lymphoma on the other. Interleukin-3 (IL-3) may contribute to both conditions. IL-3 is a pleotrophic growth factor affecting the prolif-eration and differentiation of stem cells to committed progenitors of several hematopoietic lineages including megakaryocytes and lymphocytes. The serum level of IL-3 determined by ELISA was found to be higher in a cohort of 16 patients with SLE in comparison to healthy controls. The IL-3 levels were high-est in 2 patients with SLE and lymphoma. Interestingly, low serum levels were detected in SLE patients with thrombocytopenia. Our preliminary results may point to the role of IL-3 in the hematopoietic changes observed in SLE.

Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalInternational Archives of Allergy and Immunology
Volume100
Issue number3
DOIs
StatePublished - 1993

Keywords

  • ELISA
  • Interleukin-3
  • Lymphoma
  • Systemic lupus erythematosus

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