Interleukin-3 immunoassay in systemic lupus erythematosus patients: Preliminary data

P. Fishman; M. Kamashta; M. Ehrenfeld; J. Vianna; G. R.V. Hughes; D. Sredni; R. Zigelman; G. Sabo; Y. Shoenfeld

doi:10.1159/000236414

Interleukin-3 immunoassay in systemic lupus erythematosus patients: Preliminary data

P. Fishman, M. Kamashta, M. Ehrenfeld, J. Vianna, G. R.V. Hughes, D. Sredni, R. Zigelman, G. Sabo, Y. Shoenfeld

Department of Social & Health Sciences

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18 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) may be associated with thrombocytopenia on one hand and lymphoma on the other. Interleukin-3 (IL-3) may contribute to both conditions. IL-3 is a pleotrophic growth factor affecting the prolif-eration and differentiation of stem cells to committed progenitors of several hematopoietic lineages including megakaryocytes and lymphocytes. The serum level of IL-3 determined by ELISA was found to be higher in a cohort of 16 patients with SLE in comparison to healthy controls. The IL-3 levels were high-est in 2 patients with SLE and lymphoma. Interestingly, low serum levels were detected in SLE patients with thrombocytopenia. Our preliminary results may point to the role of IL-3 in the hematopoietic changes observed in SLE.

Original language	English
Pages (from-to)	215-218
Number of pages	4
Journal	International Archives of Allergy and Immunology
Volume	100
Issue number	3
DOIs	https://doi.org/10.1159/000236414
State	Published - 1993

Keywords

ELISA
Interleukin-3
Lymphoma
Systemic lupus erythematosus

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10.1159/000236414

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abstract = "Systemic lupus erythematosus (SLE) may be associated with thrombocytopenia on one hand and lymphoma on the other. Interleukin-3 (IL-3) may contribute to both conditions. IL-3 is a pleotrophic growth factor affecting the prolif-eration and differentiation of stem cells to committed progenitors of several hematopoietic lineages including megakaryocytes and lymphocytes. The serum level of IL-3 determined by ELISA was found to be higher in a cohort of 16 patients with SLE in comparison to healthy controls. The IL-3 levels were high-est in 2 patients with SLE and lymphoma. Interestingly, low serum levels were detected in SLE patients with thrombocytopenia. Our preliminary results may point to the role of IL-3 in the hematopoietic changes observed in SLE.",

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AU - Fishman, P.

AU - Kamashta, M.

AU - Ehrenfeld, M.

AU - Vianna, J.

AU - Hughes, G. R.V.

AU - Sredni, D.

AU - Zigelman, R.

AU - Sabo, G.

AU - Shoenfeld, Y.

PY - 1993

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AB - Systemic lupus erythematosus (SLE) may be associated with thrombocytopenia on one hand and lymphoma on the other. Interleukin-3 (IL-3) may contribute to both conditions. IL-3 is a pleotrophic growth factor affecting the prolif-eration and differentiation of stem cells to committed progenitors of several hematopoietic lineages including megakaryocytes and lymphocytes. The serum level of IL-3 determined by ELISA was found to be higher in a cohort of 16 patients with SLE in comparison to healthy controls. The IL-3 levels were high-est in 2 patients with SLE and lymphoma. Interestingly, low serum levels were detected in SLE patients with thrombocytopenia. Our preliminary results may point to the role of IL-3 in the hematopoietic changes observed in SLE.

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Interleukin-3 immunoassay in systemic lupus erythematosus patients: Preliminary data

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Keywords

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