TY - JOUR
T1 - Lithium Toxicity with Severe Bradycardia Post Sleeve Gastrectomy
T2 - a Case Report and Review of the Literature
AU - Dahan, Arik
AU - Porat, Daniel
AU - Azran, Carmil
AU - Mualem, Yoni
AU - Sakran, Nasser
AU - Abu-Abeid, Subhi
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/2/15
Y1 - 2019/2/15
N2 - Lithium is one of the major treatment options in bipolar disorder. Bariatric surgery can significantly modify the oral bioavailability of drugs, and lithium is no exception; although in most cases drug absorption seems to decrease, in the case of lithium, toxicity is the risk. In this article, we describe a 61-year-old male patient presented with lithium toxicity, including newly diagnosed severe bradycardia requiring a permanent pacemaker, after undergoing sleeve gastrectomy. We discuss the mechanisms behind this case, provide potential solutions for clinicians treating bariatric patients with lithium, and review previous reports of lithium toxicity post bariatric surgery. Awareness of changes in drug absorption, particularly lithium, following bariatric surgery, is prudent and essential for optimal patient care. Close clinical and drug levels monitoring is strongly advised.
AB - Lithium is one of the major treatment options in bipolar disorder. Bariatric surgery can significantly modify the oral bioavailability of drugs, and lithium is no exception; although in most cases drug absorption seems to decrease, in the case of lithium, toxicity is the risk. In this article, we describe a 61-year-old male patient presented with lithium toxicity, including newly diagnosed severe bradycardia requiring a permanent pacemaker, after undergoing sleeve gastrectomy. We discuss the mechanisms behind this case, provide potential solutions for clinicians treating bariatric patients with lithium, and review previous reports of lithium toxicity post bariatric surgery. Awareness of changes in drug absorption, particularly lithium, following bariatric surgery, is prudent and essential for optimal patient care. Close clinical and drug levels monitoring is strongly advised.
KW - Bariatric surgery
KW - Bipolar disorder
KW - Bradycardia
KW - Drug absorption
KW - Lithium toxicity
KW - Sleeve gastrectomy
UR - http://www.scopus.com/inward/record.url?scp=85056891247&partnerID=8YFLogxK
U2 - 10.1007/s11695-018-3597-x
DO - 10.1007/s11695-018-3597-x
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C2 - 30448980
AN - SCOPUS:85056891247
SN - 0960-8923
VL - 29
SP - 735
EP - 738
JO - Obesity Surgery
JF - Obesity Surgery
IS - 2
ER -
