Liquid Copolymers as Biodegradable Surgical Sealant

Neta Shimony, Alona Shagan, Bat hen Eylon, Abraham Nyska, Adi Gross, Boaz Mizrahi

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Surgical sealants are widely used to prevent seepage of fluids and liquids, promote hemostasis, and close incisions. Despite the remarkable progress the field of biomaterials has undergone, the clinical uses of surgical sealants are limited because of their short persistence time in vivo, toxicity, and high production costs. Here, the development of two complementary neat (solvent-free) prepolymers, PEG4-PLGA-NHS and PEG4-NH2, that harden upon mixing to yield an elastic biodegradable sealant is presented. The mechanical and rheological properties and cross-linking rate can be controlled by varying the ratio between the two prepolymers. The tested sealants show a longer persistence time compared with fibrin glue, minimal cytotoxicity in vitro, and excellent biocompatibility in vivo. The neat, multiarmed approach demonstrated here improves the mechanical and biocompatibility properties and provides a promising tissue sealant solution for wound closure in future surgical procedures.

Original languageEnglish
Article number2100803
JournalAdvanced healthcare materials
Issue number19
StatePublished - 6 Oct 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 Wiley-VCH GmbH.


The research was supported by the Magneton Program of the Israeli Ministry of Commerce (grant number 69269) and by the Russell Berrie Nanotechnology Institute, Technion.

FundersFunder number
Israeli Ministry of Commerce69269
Russell Berrie Nanotechnology Institute
Technion-Israel Institute of Technology


    • PLGA
    • bioadhesives
    • hydrogels
    • polyethylene glycol
    • sealants


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