Liquid biopsy for microbiome profiling through nucleotide analysis

  • Ilana Kolodkin-Gal
  • , Milana Frenkel-Morgenstern

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Liquid biopsy for microbiome analysis is an emerging field that aims to study the composition and dynamics of microbial communities by analyzing biological fluids such as blood, urine, or saliva. This noninvasive method offers a useful approach to understanding microbiome dynamics. It provides insights into different pathologies, enables unbiased pathogen detection through noninvasive sampling, and offers rapid turnaround times. Clinical applications of liquid biopsy are emerging for microbiome exploration, particularly in areas such as infectious disease management, cancer diagnostics, and personalized medicine for chronic bowel diseases. This review highlights the role of liquid biopsy in infection and microbiome exploration, potentially revolutionizing diagnostics and tailored medicine by enabling the real-time monitoring of microbial shifts.

Original languageEnglish
Pages (from-to)389-400
Number of pages12
JournalTrends in Biotechnology
Volume44
Issue number2
Early online date18 Jun 2025
DOIs
StatePublished - Feb 2026
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2025 Elsevier Ltd

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • cell-free DNA
  • chimeric RNA
  • liquid biopsy
  • microbiome
  • pathogens
  • sequencing
  • vesicles

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