Lipid-Based Nanoparticles for Drug-Delivery Systems

Raj Kumar

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

75 Scopus citations


The discovery of new drug molecules depends on a number of steps, which limits the development of feasible new drugs for the treatment of disease without any side effects. However, most drugs fail in the clinical stage even though they showed good biological activity in in vitro and in vivo studies. This is may be due to the lack of a physiological environment during the in vitro and in vivo studies. Hence, most research and development is focusing on alternative ways to develop drug molecules that are suitable for treatment without side effects through the formulation of suitable drug-delivery systems. There are a number of processes and techniques developed for drug delivery, and one such technique is lipid-based nanoparticles as carriers for drug delivery. The major advantages of lipids are high biocompatibility and biodegradability. In this chapter, we discuss lipid-based nanocarrier systems such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and self-emulsification drug-delivery systems. The focus of this chapter is a detailed discussion of the various lipid-based nanocarrier systems, formulations, and characterization techniques. We also briefly discuss the different routes of administration of lipid-based nanoparticles and their application in drug-delivery systems for various kinds of treatment.

Original languageEnglish
Title of host publicationNanocarriers for Drug Delivery
Subtitle of host publicationNanoscience and Nanotechnology in Drug Delivery
PublisherElsevier Science Ltd.
Number of pages36
ISBN (Electronic)9780128140345
ISBN (Print)9780128140338
StatePublished - 1 Jan 2018

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc. All rights reserved.


  • Active pharmaceutical ingredient
  • Drug delivery
  • Nanocarriers
  • Nanomedicine
  • Solid lipid nanoparticles


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