TY - CHAP
T1 - Linking the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to human malignancies
AU - Kalt, Inna
AU - Masa, Shiri Rivka
AU - Sarid, Ronit
PY - 2009
Y1 - 2009
N2 - In 1994, the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) was identified as the etiologic agent of Kaposi's sarcoma (KS). KSHV has since been associated with two additional malignancies: primary effusion lymphoma and multicentric Castleman's disease. In this chapter, we describe the current understanding of the pathogenesis, transmission, and prevalence of KSHV, and its association mainly with KS. We describe evidence demonstrating that KSHV is a causative agent for KS, and we present other factors that possibly contribute to the incidence of KS. We compare worldwide data on the prevalence of KS and of KSHV infection. Specific viral genes that may induce KS tumors or enable their growth also are described. Finally, we discuss the implications of the transmission modes and epidemiology of this virus on recommendations for KSHV screening of tissues and blood products before transplantation or transfusion.
AB - In 1994, the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) was identified as the etiologic agent of Kaposi's sarcoma (KS). KSHV has since been associated with two additional malignancies: primary effusion lymphoma and multicentric Castleman's disease. In this chapter, we describe the current understanding of the pathogenesis, transmission, and prevalence of KSHV, and its association mainly with KS. We describe evidence demonstrating that KSHV is a causative agent for KS, and we present other factors that possibly contribute to the incidence of KS. We compare worldwide data on the prevalence of KS and of KSHV infection. Specific viral genes that may induce KS tumors or enable their growth also are described. Finally, we discuss the implications of the transmission modes and epidemiology of this virus on recommendations for KSHV screening of tissues and blood products before transplantation or transfusion.
KW - Human herpesvirus 8 (HHV-8)
KW - Kaposi's sarcoma (KS)
KW - Kaposi's sarcoma-associated herpesvirus (KSHV)
KW - Multicentric Castleman's disease (MCD)
KW - Primary effusion lymphoma (PEL)
UR - http://www.scopus.com/inward/record.url?scp=60349122854&partnerID=8YFLogxK
U2 - 10.1007/978-1-59745-416-2_19
DO - 10.1007/978-1-59745-416-2_19
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C2 - 19109790
AN - SCOPUS:60349122854
SN - 9781588299871
T3 - Methods in Molecular Biology
SP - 387
EP - 407
BT - Cancer Epidemiology
A2 - Verma, Mukesh
ER -