Linking resting-state networks and social cognition in schizophrenia and bipolar disorder

Amy M. Jimenez, Philipp Riedel, Junghee Lee, Eric A. Reavis, Michael F. Green

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Individuals with schizophrenia and bipolar disorder show alterations in functional neural connectivity during rest. However, resting-state network (RSN) disruptions have not been systematically compared between the two disorders. Further, the impact of RSN disruptions on social cognition, a key determinant of functional outcome, has not been studied. Forty-eight individuals with schizophrenia, 46 with bipolar disorder, and 48 healthy controls completed resting-state functional magnetic resonance imaging. An atlas-based approach was used to examine functional connectivity within nine RSNs across the cortex. RSN connectivity was assessed via nonparametric permutation testing, and associations with performance on emotion perception, mentalizing, and emotion management tasks were examined. Group differences were observed in the medial and lateral visual networks and the sensorimotor network. Individuals with schizophrenia demonstrated reduced connectivity relative to healthy controls in all three networks. Individuals with bipolar disorder demonstrated reduced connectivity relative to controls in the medial visual network and connectivity within this network was significantly positively correlated with emotion management. In healthy controls, connectivity within the medial and lateral visual networks positively correlated with mentalizing. No significant correlations were found for either visual network in schizophrenia. Results highlight the role of altered early visual processing in social cognitive deficits in both schizophrenia and bipolar disorder. However, individuals with bipolar disorder appear to compensate for disrupted visual network connectivity on social cognitive tasks, whereas those with schizophrenia do not. The current study adds clarity on the neurophysiology underlying social cognitive deficits that result in impaired functioning in serious mental illness.

Original languageEnglish
Pages (from-to)4703-4715
Number of pages13
JournalHuman Brain Mapping
Issue number16
StatePublished - 1 Nov 2019
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by the National Institute of Mental Health R01MH095878 to M.F.G. The funder had no role in the study design, data collection, management, analysis and interpretation, decision to publish, or the preparation, review or approval of the manuscript. The authors would like to thank Ana Ceci Myers, Julio Iglesias, and the rest of the laboratory staff for assistance in data collection, and Michelle J. Dolinsky for assistance with participant recruitment. The authors would also like to thank One Mind—Center for Cognitive Neuroscience at UCLA for their generous support to the CCN scanner. fMRI data analysis for this study used computational and storage services associated with the Hoffman2 Shared Cluster provided by UCLA Institute for Digital Research and Education's Research Technology Group.

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.


  • bipolar disorder
  • resting-state fMRI
  • schizophrenia
  • social cognition


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