Linguistic features of noncoding DNA sequences

R. N. Mantegna; S. V. Buldyrev; A. L. Goldberger; S. Havlin; C. K. Peng; M. Simons; H. E. Stanley

doi:10.1103/physrevlett.73.3169

Linguistic features of noncoding DNA sequences

R. N. Mantegna, S. V. Buldyrev, A. L. Goldberger, S. Havlin, C. K. Peng, M. Simons, H. E. Stanley

Research output: Contribution to journal › Article › peer-review

251 Scopus citations

Abstract

We extend the Zipf approach to analyzing linguistic texts to the statistical study of DNA base pair sequences and find that the noncoding regions are more similar to natural languages than the coding regions. We also adapt the Shannon approach to quantifying the "redundancy" of a linguistic text in terms of a measurable entropy function, and demonstrate that noncoding regions in eukaryotes display a smaller entropy and larger redundancy than coding regions, supporting the possibility that noncoding regions of DNA may carry biological information.

Original language	English
Pages (from-to)	3169-3172
Number of pages	4
Journal	Physical Review Letters
Volume	73
Issue number	23
DOIs	https://doi.org/10.1103/physrevlett.73.3169
State	Published - 5 Dec 1994
Externally published	Yes

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AU - Goldberger, A. L.

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AU - Simons, M.

AU - Stanley, H. E.

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Linguistic features of noncoding DNA sequences

Abstract

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