Limbic dopaminergic adaptation to a stressful stimulus in a rat model of depression

Gal Yadid; David H. Overstreet; Abraham Zangen

doi:10.1016/s0006-8993(00)03248-0

Limbic dopaminergic adaptation to a stressful stimulus in a rat model of depression

Gal Yadid
, David H. Overstreet
, Abraham Zangen

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

University of North Carolina at Chapel Hill
Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

The dopaminergic mesolimbic system has a key role in motivation and reward, and stressful stimuli appear to alter its functionality. Since stress is considered to be one of the primary factors that mediate the expression of depressive behavior, dopamine and its metabolites in the nucleus accumbens of control and Flinders Sensitive Line rats, an animal model of depression, were examined prior to and after a forced swim test. In both types of rats, the levels of dopamine metabolites markedly decreased after the forced swimming, albeit to different extents. In contrast, 60 min after the swim test, dopamine levels were elevated only in the control rats. The accumbal dopaminergic activity is discussed in relation to the behavior of 'depressed' and normal rat lines subjected to a stressful event.

Original language	English
Pages (from-to)	43-47
Number of pages	5
Journal	Brain Research
Volume	896
Issue number	1-2
DOIs	https://doi.org/10.1016/s0006-8993(00)03248-0
State	Published - 30 Mar 2001

Bibliographical note

Funding Information:
This research was supported in part by grants from the Bar-Ilan Research Foundation, (no. 2520) and the National Institute for Psychobiology in Israel (no. 3299) to Gal Yadid.

Funding

This research was supported in part by grants from the Bar-Ilan Research Foundation, (no. 2520) and the National Institute for Psychobiology in Israel (no. 3299) to Gal Yadid.

Funders	Funder number
Bar-Ilan Research Foundation	2520
National Institute for Psychobiology in Israel	3299

Keywords

Animal model
Depression
Dopamine
Stress
Swim test

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10.1016/s0006-8993(00)03248-0

Cite this

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title = "Limbic dopaminergic adaptation to a stressful stimulus in a rat model of depression",

abstract = "The dopaminergic mesolimbic system has a key role in motivation and reward, and stressful stimuli appear to alter its functionality. Since stress is considered to be one of the primary factors that mediate the expression of depressive behavior, dopamine and its metabolites in the nucleus accumbens of control and Flinders Sensitive Line rats, an animal model of depression, were examined prior to and after a forced swim test. In both types of rats, the levels of dopamine metabolites markedly decreased after the forced swimming, albeit to different extents. In contrast, 60 min after the swim test, dopamine levels were elevated only in the control rats. The accumbal dopaminergic activity is discussed in relation to the behavior of 'depressed' and normal rat lines subjected to a stressful event.",

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Limbic dopaminergic adaptation to a stressful stimulus in a rat model of depression

Abstract

Bibliographical note

Funding

Keywords

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