Lesion of a serotonergic modulatory neuron in Aplysia produces a specific defect in feeding behavior

Steven C. Rosen, Irving Kupfermann, Ronald S. Goldstein, Klaudiusz R. Weiss

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The serotonergic metacerebral cells (MCCs) of Aplysia were destroyed by intracellular injection of proteolytic enzyme. MCC-lesioned animals showed alterations of biting responses compared to MCC-sham and B-cell-lesioned control animals, as well as to their own preoperative behavior. The alterations of biting responses included a prolongation of the duration of radula protraction and a lengthening of interbite interval. No changes were observed in non-biting feeding responses and in behaviors unrelated to feeding.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalBrain Research
Volume260
Issue number1
DOIs
StatePublished - 31 Jan 1983
Externally publishedYes

Funding

FundersFunder number
National Institute of Mental HealthR01MH035564

    Keywords

    • arousal
    • feeding
    • hunger
    • lesion
    • mollusc
    • neuromodulation
    • serotonin

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